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- W1993432397 abstract "Decreased longitudinal growth was observed in 24 hyperkinetic children receiving pemoline therapy. Mean height velocity was 3.67±0.25 cm/year during therapy but 5.35±0.42 cm/year after treatment had been discontinued (P<0.01). There appeared to be an inverse relationship between growth velocity and drug dosage. All patients receiving less than the median dose of 3.72 mg/kg grew 4 cm/year or more, while seven of 12 patients receiving more than this dose grew at a slower rate. Body weight, basal and stimulated growth hormone values, and plasma somatomedin concentrations were not significantly altered by pemoline treatment, suggesting that this drug may have a direct effect on cartilage metabolism. Decreased longitudinal growth was observed in 24 hyperkinetic children receiving pemoline therapy. Mean height velocity was 3.67±0.25 cm/year during therapy but 5.35±0.42 cm/year after treatment had been discontinued (P<0.01). There appeared to be an inverse relationship between growth velocity and drug dosage. All patients receiving less than the median dose of 3.72 mg/kg grew 4 cm/year or more, while seven of 12 patients receiving more than this dose grew at a slower rate. Body weight, basal and stimulated growth hormone values, and plasma somatomedin concentrations were not significantly altered by pemoline treatment, suggesting that this drug may have a direct effect on cartilage metabolism." @default.
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- W1993432397 date "1979-04-01" @default.
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- W1993432397 title "Impaired growth in hyperkinetic children receiving pemoline" @default.
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- W1993432397 doi "https://doi.org/10.1016/s0022-3476(79)80006-2" @default.
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