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- W1993433059 abstract "Growth factor—receptor interactions at the cell surface eventually leading to the transcriptional activation of immediate early genes is mediated by the mitogen‐activated protein kinase (MAP kinase/MAPK) cascade. Here we show that overexpression of extracellular signal‐regulated kinase 1 (ERK1) cDNA, encoding p44 mapk , results in the activation of Elk‐1, the serum response factor accessory protein. We also show that overexpression of ERK2, encoding p42 mapk , activates Myc, but not Elk‐1. Therefore, the MAP kinase cascade diverges with at least one specific target for each MAP kinase isoform and provides a novel mechanism for differential regulation of this signaling pathway." @default.
- W1993433059 created "2016-06-24" @default.
- W1993433059 creator A5047822350 @default.
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- W1993433059 date "1994-06-13" @default.
- W1993433059 modified "2023-10-14" @default.
- W1993433059 title "Functional divergence of the MAP kinase pathway ERK1 and ERK2 activate specific transcription factors" @default.
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- W1993433059 doi "https://doi.org/10.1016/0014-5793(94)00480-3" @default.
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