FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993433963> ?p ?o ?g. }

• W1993433963 endingPage "194" @default.
• W1993433963 startingPage "183" @default.
• W1993433963 abstract "During endochondral ossification hypertrophic chondrocytes in the growth plate of fetal long bones, ribs and vertebrae play a key role in preparing growth plate cartilage for replacement by bone. In order to establish a reporter gene mouse to facilitate functional analysis of genes expressed in hypertrophic chondrocytes in this process, Col10a1- BAC reporter gene mouse lines were established expressing LacZ specifically in hypertrophic cartilage under the control of the complete Col10a1 gene. For this purpose, a bacterial artificial chromosome (BAC RP23-192A7) containing the entire murine Col10a1 gene together with 200 kb flanking sequences was modified by inserting a LacZ-Neo cassette into the second exon of Col10a1 by homologous recombination in E. coli. Transgenic mice containing between one and seven transgene copies were generated by injection of the purified BAC-Col10a1- lLacZ DNA. X-gal staining of newborns and embryos revealed strong and robust LacZ activity exclusively in hypertrophic cartilage of the fetal and neonatal skeleton of the transgenic offspring. This indicates that expression of the reporter gene in its proper genomic context in the BAC Col10a1 environment is independent of the integration site and reflects authentic Col10a1 expression in vivo. The Col10a1 specific BAC recombination vector described here will enable the specific analysis of effector gene functions in hypertrophic cartilage during skeletal development, endochondral ossification, and fracture callus healing." @default.
• W1993433963 created "2016-06-24" @default.
• W1993433963 creator A5001618888 @default.
• W1993433963 creator A5006227422 @default.
• W1993433963 creator A5022358546 @default.
• W1993433963 creator A5024660369 @default.
• W1993433963 creator A5043749718 @default.
• W1993433963 creator A5046206971 @default.
• W1993433963 creator A5057469947 @default.
• W1993433963 creator A5071069384 @default.
• W1993433963 creator A5084667140 @default.
• W1993433963 date "2006-10-19" @default.
• W1993433963 modified "2023-10-13" @default.
• W1993433963 title "BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter" @default.
• W1993433963 cites W145700735 @default.
• W1993433963 cites W1553594457 @default.
• W1993433963 cites W187682638 @default.
• W1993433963 cites W1963769216 @default.
• W1993433963 cites W1965073410 @default.
• W1993433963 cites W1969108838 @default.
• W1993433963 cites W1972979483 @default.
• W1993433963 cites W1978943338 @default.
• W1993433963 cites W1990787421 @default.
• W1993433963 cites W1992994796 @default.
• W1993433963 cites W1993148327 @default.
• W1993433963 cites W1999322873 @default.
• W1993433963 cites W2000291668 @default.
• W1993433963 cites W2007982185 @default.
• W1993433963 cites W2008205503 @default.
• W1993433963 cites W2027625111 @default.
• W1993433963 cites W2037834645 @default.
• W1993433963 cites W2045860850 @default.
• W1993433963 cites W2049157134 @default.
• W1993433963 cites W2051244230 @default.
• W1993433963 cites W2063578899 @default.
• W1993433963 cites W2064398859 @default.
• W1993433963 cites W2066504997 @default.
• W1993433963 cites W2074346944 @default.
• W1993433963 cites W2075700473 @default.
• W1993433963 cites W2079475603 @default.
• W1993433963 cites W2082575625 @default.
• W1993433963 cites W2090567773 @default.
• W1993433963 cites W2093241467 @default.
• W1993433963 cites W2096066885 @default.
• W1993433963 cites W2102326832 @default.
• W1993433963 cites W2102894828 @default.
• W1993433963 cites W2115487032 @default.
• W1993433963 cites W2121032356 @default.
• W1993433963 cites W2127928194 @default.
• W1993433963 cites W2128016314 @default.
• W1993433963 cites W2135917978 @default.
• W1993433963 cites W2136670217 @default.
• W1993433963 cites W2144329461 @default.
• W1993433963 cites W2152845055 @default.
• W1993433963 cites W2167802527 @default.
• W1993433963 cites W2398602248 @default.
• W1993433963 cites W2410308718 @default.
• W1993433963 cites W2438551272 @default.
• W1993433963 doi "https://doi.org/10.1007/s00418-006-0236-8" @default.
• W1993433963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1779629" @default.
• W1993433963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17051351" @default.
• W1993433963 hasPublicationYear "2006" @default.
• W1993433963 type Work @default.
• W1993433963 sameAs 1993433963 @default.
• W1993433963 citedByCount "27" @default.
• W1993433963 countsByYear W19934339632012 @default.
• W1993433963 countsByYear W19934339632013 @default.
• W1993433963 countsByYear W19934339632014 @default.
• W1993433963 countsByYear W19934339632015 @default.
• W1993433963 countsByYear W19934339632016 @default.
• W1993433963 countsByYear W19934339632018 @default.
• W1993433963 countsByYear W19934339632019 @default.
• W1993433963 countsByYear W19934339632021 @default.
• W1993433963 countsByYear W19934339632022 @default.
• W1993433963 crossrefType "journal-article" @default.
• W1993433963 hasAuthorship W1993433963A5001618888 @default.
• W1993433963 hasAuthorship W1993433963A5006227422 @default.
• W1993433963 hasAuthorship W1993433963A5022358546 @default.
• W1993433963 hasAuthorship W1993433963A5024660369 @default.
• W1993433963 hasAuthorship W1993433963A5043749718 @default.
• W1993433963 hasAuthorship W1993433963A5046206971 @default.
• W1993433963 hasAuthorship W1993433963A5057469947 @default.
• W1993433963 hasAuthorship W1993433963A5071069384 @default.
• W1993433963 hasAuthorship W1993433963A5084667140 @default.
• W1993433963 hasBestOaLocation W19934339631 @default.
• W1993433963 hasConcept C102230213 @default.
• W1993433963 hasConcept C104317684 @default.
• W1993433963 hasConcept C105702510 @default.
• W1993433963 hasConcept C141231307 @default.
• W1993433963 hasConcept C150194340 @default.
• W1993433963 hasConcept C153911025 @default.
• W1993433963 hasConcept C161733203 @default.
• W1993433963 hasConcept C17938293 @default.
• W1993433963 hasConcept C182901222 @default.
• W1993433963 hasConcept C2780550940 @default.
• W1993433963 hasConcept C2781403057 @default.
• W1993433963 hasConcept C54355233 @default.
• W1993433963 hasConcept C86803240 @default.

• next