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- W1993438222 abstract "An unknown impurity detected in small amounts during the heat treatment of artesunate-amodiaquine bilayer tablets was purified by semipreparative HPLC and identified by MS and NMR as the tetrahydrofuranyl acetate-rearranged derivative of anhydrodihydroartemisinin. When anhydrodihydroartemisinin was treated with a Fe(II) salt in acetonitrile-water solution, the same product was generated, together with an isomeric 2-deoxy-4α-hydroxy-anhydrodihydroartemisinin derivative, as expected from the usual homolytic radical opening of the endoperoxide bond previously described for other artemisinin derivatives." @default.
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- W1993438222 date "2013-07-01" @default.
- W1993438222 modified "2023-10-16" @default.
- W1993438222 title "A new derivative detected in accelerated ageing of artesunate-amodiaquine fixed dose combination tablets" @default.
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- W1993438222 doi "https://doi.org/10.1016/j.jpba.2013.03.009" @default.
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