FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993440026> ?p ?o ?g. }

• W1993440026 endingPage "912" @default.
• W1993440026 startingPage "901" @default.
• W1993440026 abstract "The aim of this study is to prepare a stable phosphatidylcholine/bile salt micelles with Pluronic F127-polyethylenimine conjugates (F127-PEI), d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), soybean phosphatidylcholine (SPC) and sodium cholate (NaC) and to elucidate the effects and possible mechanism of micelle components on the intestinal absorption of paclitaxel (PTX) in rats. The results of intestinal absorption revealed that the PTX in SPC/NaC micelles displayed superior permeability across intestinal barrier than free drug and PTX in TPGS/SPC/NaC and F127-PEI/TPGS/SPC/NaC mixed micelles exhibited the strongest permeability across intestinal barrier. These results were also proved by the studies on cell uptake tests. The mechanism was demonstrated in connection with inhibition of the efflux mediated by intestinal P-gp and enhancement of the drug transportation across the unstirred water layer to the endothelial lining, thereby promoting the permeation across the intestinal wall. Pharmacokinetic study demonstrated that the area under the plasma concentration-time curve (AUC0→∞) of paclitaxel in F127-PEI/TPGS/SPC/NaC micelles was much greater than that in TPGS/SPC/NaC micelles. This phenomenon deviated from the results of uptake studies by cells and permeability experiments through rat intestine and revealed that the micelle stability had a great effect on intestinal absorption of paclitaxel." @default.
• W1993440026 created "2016-06-24" @default.
• W1993440026 creator A5005171810 @default.
• W1993440026 creator A5019613091 @default.
• W1993440026 creator A5061940048 @default.
• W1993440026 creator A5085356073 @default.
• W1993440026 date "2014-07-31" @default.
• W1993440026 modified "2023-09-23" @default.
• W1993440026 title "Stable phosphatidylcholine-bile salt mixed micelles enhance oral absorption of paclitaxel: preparation and mechanism in rats" @default.
• W1993440026 cites W1560355462 @default.
• W1993440026 cites W1588092478 @default.
• W1993440026 cites W176809139 @default.
• W1993440026 cites W1965688487 @default.
• W1993440026 cites W1968436748 @default.
• W1993440026 cites W1971173488 @default.
• W1993440026 cites W1973053894 @default.
• W1993440026 cites W1975081668 @default.
• W1993440026 cites W1981912612 @default.
• W1993440026 cites W1986124680 @default.
• W1993440026 cites W2001629813 @default.
• W1993440026 cites W2018879159 @default.
• W1993440026 cites W2024526439 @default.
• W1993440026 cites W2025141250 @default.
• W1993440026 cites W2030680926 @default.
• W1993440026 cites W2038093943 @default.
• W1993440026 cites W2048969741 @default.
• W1993440026 cites W2051759959 @default.
• W1993440026 cites W2053122338 @default.
• W1993440026 cites W2059617501 @default.
• W1993440026 cites W2063108311 @default.
• W1993440026 cites W2068212416 @default.
• W1993440026 cites W2076708105 @default.
• W1993440026 cites W2079613420 @default.
• W1993440026 cites W2091084349 @default.
• W1993440026 cites W2091400260 @default.
• W1993440026 cites W2105547623 @default.
• W1993440026 cites W2160168727 @default.
• W1993440026 doi "https://doi.org/10.3109/1061186x.2014.945090" @default.
• W1993440026 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25077358" @default.
• W1993440026 hasPublicationYear "2014" @default.
• W1993440026 type Work @default.
• W1993440026 sameAs 1993440026 @default.
• W1993440026 citedByCount "7" @default.
• W1993440026 countsByYear W19934400262015 @default.
• W1993440026 countsByYear W19934400262016 @default.
• W1993440026 countsByYear W19934400262020 @default.
• W1993440026 countsByYear W19934400262021 @default.
• W1993440026 countsByYear W19934400262022 @default.
• W1993440026 crossrefType "journal-article" @default.
• W1993440026 hasAuthorship W1993440026A5005171810 @default.
• W1993440026 hasAuthorship W1993440026A5019613091 @default.
• W1993440026 hasAuthorship W1993440026A5061940048 @default.
• W1993440026 hasAuthorship W1993440026A5085356073 @default.
• W1993440026 hasConcept C101335993 @default.
• W1993440026 hasConcept C104317684 @default.
• W1993440026 hasConcept C11268172 @default.
• W1993440026 hasConcept C120882062 @default.
• W1993440026 hasConcept C125287762 @default.
• W1993440026 hasConcept C12554922 @default.
• W1993440026 hasConcept C141071460 @default.
• W1993440026 hasConcept C15920480 @default.
• W1993440026 hasConcept C159985019 @default.
• W1993440026 hasConcept C178790620 @default.
• W1993440026 hasConcept C184651966 @default.
• W1993440026 hasConcept C185154212 @default.
• W1993440026 hasConcept C185592680 @default.
• W1993440026 hasConcept C192562407 @default.
• W1993440026 hasConcept C2775925850 @default.
• W1993440026 hasConcept C2776330855 @default.
• W1993440026 hasConcept C2776694085 @default.
• W1993440026 hasConcept C2776964284 @default.
• W1993440026 hasConcept C2777292972 @default.
• W1993440026 hasConcept C2778918659 @default.
• W1993440026 hasConcept C2911023556 @default.
• W1993440026 hasConcept C41625074 @default.
• W1993440026 hasConcept C43617362 @default.
• W1993440026 hasConcept C521977710 @default.
• W1993440026 hasConcept C54009773 @default.
• W1993440026 hasConcept C55493867 @default.
• W1993440026 hasConcept C60903277 @default.
• W1993440026 hasConcept C71924100 @default.
• W1993440026 hasConcept C86803240 @default.
• W1993440026 hasConcept C98274493 @default.
• W1993440026 hasConceptScore W1993440026C101335993 @default.
• W1993440026 hasConceptScore W1993440026C104317684 @default.
• W1993440026 hasConceptScore W1993440026C11268172 @default.
• W1993440026 hasConceptScore W1993440026C120882062 @default.
• W1993440026 hasConceptScore W1993440026C125287762 @default.
• W1993440026 hasConceptScore W1993440026C12554922 @default.
• W1993440026 hasConceptScore W1993440026C141071460 @default.
• W1993440026 hasConceptScore W1993440026C15920480 @default.
• W1993440026 hasConceptScore W1993440026C159985019 @default.
• W1993440026 hasConceptScore W1993440026C178790620 @default.
• W1993440026 hasConceptScore W1993440026C184651966 @default.
• W1993440026 hasConceptScore W1993440026C185154212 @default.
• W1993440026 hasConceptScore W1993440026C185592680 @default.
• W1993440026 hasConceptScore W1993440026C192562407 @default.
• W1993440026 hasConceptScore W1993440026C2775925850 @default.

• next