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• W1993448230 abstract "The effect of intrathecal galanin (GAL) on the hamstring flexor reflex to sural nerve stimulation was compared in rats with intact and unilaterally sectioned sciatic nerves. GAL had a biphasic effect on the flexor reflex in rats with intact nerves, including facilitation, facilitation followed by depression and pure depression, in a dose-dependent manner. In axotomized rats, the depressive effect of GAL was significantly increased, occurring at lower drug concentrations. Furthermore, the degree of depression was significantly stronger with a more rapid onset after nerve section. It is concluded that along with an increase in GAL-like immunoreactivity in primary afferents, the inhibitory function of this neuropeptide is enhanced following axotomy. This functional change may be due to both pre- and postsynaptic mechanisms." @default.
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• W1993448230 date "1989-10-01" @default.
• W1993448230 modified "2023-10-11" @default.
• W1993448230 title "The effect of intrathecal galanin on the flexor reflex in rat: Increased depression after sciatic nerve section" @default.
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• W1993448230 doi "https://doi.org/10.1016/0304-3940(89)90027-x" @default.
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