Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993450525> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1993450525 endingPage "17" @default.
- W1993450525 startingPage "13" @default.
- W1993450525 abstract "We report that the loop diuretic drugs bumetanide and furosemide used in the treatment of hypertension are GPR35 agonists. We utilized calcium flux, inositol phosphate accumulation, and dynamic redistribution assays to examine the pharmacology of these compounds on the human, mouse and rat GPR35. While potent on human GPR35, neither bumetanide nor furosemide were active against mouse or rat GPR35. Furthermore, the Na<sup>+</sup>-Cl<sup>–</sup> cotransporter inhibi- tors chlorothiazide and hydrochlorothiazide were inactive against GPR35 in all three species. We also demonstrate that GPR35 is expressed in human skin where it has been shown that loop diuretics inhibit histamine-induced flare and itch response. These findings suggest that GPR35 may play an important role in skin cell biology and be a potential target for the treatment of a variety of immune disorders." @default.
- W1993450525 created "2016-06-24" @default.
- W1993450525 creator A5000268016 @default.
- W1993450525 creator A5019469481 @default.
- W1993450525 creator A5027384607 @default.
- W1993450525 creator A5072096793 @default.
- W1993450525 date "2012-01-01" @default.
- W1993450525 modified "2023-09-26" @default.
- W1993450525 title "GPR35 Is a Target of the Loop Diuretic Drugs Bumetanide and Furosemide" @default.
- W1993450525 cites W1496442060 @default.
- W1993450525 cites W1982830863 @default.
- W1993450525 cites W1984584304 @default.
- W1993450525 cites W1991919835 @default.
- W1993450525 cites W1995179747 @default.
- W1993450525 cites W1996095240 @default.
- W1993450525 cites W2035968282 @default.
- W1993450525 cites W2065156829 @default.
- W1993450525 cites W2065390030 @default.
- W1993450525 cites W2068322927 @default.
- W1993450525 cites W2075639694 @default.
- W1993450525 cites W2088395718 @default.
- W1993450525 cites W2122894850 @default.
- W1993450525 cites W2132461193 @default.
- W1993450525 doi "https://doi.org/10.1159/000335127" @default.
- W1993450525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22236570" @default.
- W1993450525 hasPublicationYear "2012" @default.
- W1993450525 type Work @default.
- W1993450525 sameAs 1993450525 @default.
- W1993450525 citedByCount "23" @default.
- W1993450525 countsByYear W19934505252012 @default.
- W1993450525 countsByYear W19934505252013 @default.
- W1993450525 countsByYear W19934505252014 @default.
- W1993450525 countsByYear W19934505252015 @default.
- W1993450525 countsByYear W19934505252017 @default.
- W1993450525 countsByYear W19934505252018 @default.
- W1993450525 countsByYear W19934505252019 @default.
- W1993450525 countsByYear W19934505252021 @default.
- W1993450525 countsByYear W19934505252022 @default.
- W1993450525 countsByYear W19934505252023 @default.
- W1993450525 crossrefType "journal-article" @default.
- W1993450525 hasAuthorship W1993450525A5000268016 @default.
- W1993450525 hasAuthorship W1993450525A5019469481 @default.
- W1993450525 hasAuthorship W1993450525A5027384607 @default.
- W1993450525 hasAuthorship W1993450525A5072096793 @default.
- W1993450525 hasConcept C126322002 @default.
- W1993450525 hasConcept C134018914 @default.
- W1993450525 hasConcept C178790620 @default.
- W1993450525 hasConcept C185592680 @default.
- W1993450525 hasConcept C188053792 @default.
- W1993450525 hasConcept C2777955127 @default.
- W1993450525 hasConcept C2778212192 @default.
- W1993450525 hasConcept C2779660313 @default.
- W1993450525 hasConcept C2779918671 @default.
- W1993450525 hasConcept C2780361556 @default.
- W1993450525 hasConcept C2781117629 @default.
- W1993450525 hasConcept C537181965 @default.
- W1993450525 hasConcept C71924100 @default.
- W1993450525 hasConcept C84393581 @default.
- W1993450525 hasConcept C86803240 @default.
- W1993450525 hasConcept C98274493 @default.
- W1993450525 hasConceptScore W1993450525C126322002 @default.
- W1993450525 hasConceptScore W1993450525C134018914 @default.
- W1993450525 hasConceptScore W1993450525C178790620 @default.
- W1993450525 hasConceptScore W1993450525C185592680 @default.
- W1993450525 hasConceptScore W1993450525C188053792 @default.
- W1993450525 hasConceptScore W1993450525C2777955127 @default.
- W1993450525 hasConceptScore W1993450525C2778212192 @default.
- W1993450525 hasConceptScore W1993450525C2779660313 @default.
- W1993450525 hasConceptScore W1993450525C2779918671 @default.
- W1993450525 hasConceptScore W1993450525C2780361556 @default.
- W1993450525 hasConceptScore W1993450525C2781117629 @default.
- W1993450525 hasConceptScore W1993450525C537181965 @default.
- W1993450525 hasConceptScore W1993450525C71924100 @default.
- W1993450525 hasConceptScore W1993450525C84393581 @default.
- W1993450525 hasConceptScore W1993450525C86803240 @default.
- W1993450525 hasConceptScore W1993450525C98274493 @default.
- W1993450525 hasIssue "1-2" @default.
- W1993450525 hasLocation W19934505251 @default.
- W1993450525 hasLocation W19934505252 @default.
- W1993450525 hasOpenAccess W1993450525 @default.
- W1993450525 hasPrimaryLocation W19934505251 @default.
- W1993450525 hasRelatedWork W1984049977 @default.
- W1993450525 hasRelatedWork W1993450525 @default.
- W1993450525 hasRelatedWork W1996656549 @default.
- W1993450525 hasRelatedWork W1997027413 @default.
- W1993450525 hasRelatedWork W2020344899 @default.
- W1993450525 hasRelatedWork W2062815836 @default.
- W1993450525 hasRelatedWork W2065500254 @default.
- W1993450525 hasRelatedWork W2160350069 @default.
- W1993450525 hasRelatedWork W2193846846 @default.
- W1993450525 hasRelatedWork W2488998358 @default.
- W1993450525 hasVolume "89" @default.
- W1993450525 isParatext "false" @default.
- W1993450525 isRetracted "false" @default.
- W1993450525 magId "1993450525" @default.
- W1993450525 workType "article" @default.