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• W1993456109 abstract "Background and aimsAdiponectin plays important roles in the regulation of insulin action and metabolism of glucose and lipids. We investigated whether ADIPOQ genetic variants are associated with serum lipid levels in Korean children and whether those influences might be modulated by dietary factors such as dietary monounsaturated fatty acid to saturated fatty acid ratio (MUFA:SFA).Method and resultsThe study included a population-based sample of 687 children aged 7–11 years in Gwacheon city, Kyunggi Province, Korea. Anthropometric and biochemical measurements and ADIPOQ genotype (−11377 C/G, +45 T/G, and +276 G/T) were determined. Dietary intake was estimated with a self reported 3-day food diary. The −11377 G allele carriers had significantly higher serum total cholesterol and LDL cholesterol compared to non-carriers. When dietary MUFA:SFA ratio was dichotomized (MUFA:SFA ≥1 or <1), the aggravating effects of the minor allele on serum total and LDL cholesterol were only present when the MUFA:SFA ratio was <1. Additionally, we observed that the ADIPOQ haplotype influenced serum total and LDL cholesterol levels. G–T–G haplotype carriers had higher total and LDL cholesterol levels than non-G–T–G carriers. The deleterious effect of ADIPOQ G–T–G haplotype to increase serum total and LDL cholesterol could be seen only when the MUFA:SFA ratio was <1.ConclusionIn this present study, we found interaction effects between ADIPOQ genetic variants and dietary MUFA:SFA ratio on serum lipid levels in Korean children. These results suggest that individual genetic information and dietary fatty acid intake information should be assessed together to achieve an effective outcome for reducing the atherogenic lipid profile." @default.
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• W1993456109 date "2014-01-01" @default.
• W1993456109 modified "2023-09-24" @default.
• W1993456109 title "Interactions between ADIPOQ gene variants and dietary monounsaturated: saturated fatty acid ratio on serum lipid levels in Korean children" @default.
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• W1993456109 doi "https://doi.org/10.1016/j.numecd.2013.04.007" @default.
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