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• W1993462669 abstract "In this study, we synthesised iron oxide nanocrystals (Fe2O3-NC) from goat blood (bio-precursor) using red blood cells (RBC) lysis method (a molecular level approach) for the first time. The formation of Fe2O3-NC was achieved through a single-phase chemical reduction method. The size distribution of Fe2O3-NC falls between 20–30 nm for pellet and 100–200 nm for lysate and were found to be crystalline. Fe2O3-NC demonstrated significant cytotoxicity on A549. We report the direct visualization of interactions between Fe2O3-NC and the cancer cell nucleus. The active transport of Fe2O3-NC to the nucleus induces major changes to nuclear phenotype via nuclear envelope invaginations. We further examined the root cause for the involvement of Fe2O3-NC on the expression of caspase-3, caspase-7 and Bcl-2 in A549 cancer cells. This functional proteomic analysis clearly implies that the lung cancer cell proliferation is perfectly targeted by the biosynthesised Fe2O3-NC which could provide new insight for nuclear-targeted cancer therapy." @default.
• W1993462669 created "2016-06-24" @default.
• W1993462669 creator A5051321247 @default.
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• W1993462669 date "2013-09-01" @default.
• W1993462669 modified "2023-09-27" @default.
• W1993462669 title "Goat red blood cells as precursor for iron oxide nanocrystal synthesis to develop nuclear targeted lung cancer therapy" @default.
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• W1993462669 doi "https://doi.org/10.1016/j.materresbull.2013.04.079" @default.
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