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- W1993463403 abstract "Both SKF-82958 and N-0923, selective full D1-like and D2-like agonists, respectively, given IM produced contraversive circling and reduced neurologic deficits in six MPTP-induced hemiparkinsonian monkeys. A small fixed dose of N-0923 (10 micrograms/kg) and increasing doses of SKF-82958 (23.4-234 micrograms/kg) in combination were synergistic or antagonistic in this animal model. A small dose (23.4 micrograms/kg) of SKF-82958, in combination with N-0923, caused potentiation, an intermediate dose (74.8 micrograms/kg) in combination produced additive effects, while a very large dose (234 micrograms/kg) in combination produced antagonism. All three doses of SKF-82958 prolonged the duration of action of a small dose (10 ng/kg) of N-0923. Selective D1-like and D2-like agonists should be studied as potential therapeutic agents alone and in combination in human idiopathic parkinsonism, especially using low and intermediate doses." @default.
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- W1993463403 date "1997-01-01" @default.
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- W1993463403 title "Selective Full Dopamine D1-Like (SKF-82958) and D2-Like (N-0923) Agonist Combination in the MPTP Monkey Model of Hemiparkinsonism" @default.
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- W1993463403 doi "https://doi.org/10.1016/s0361-9230(96)00346-2" @default.
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