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- W1993463781 abstract "The intestinal epithelium sits at the interface between an organism and its luminal environment, and as such is prone to oxidative damage induced by luminal oxidants. Mucosal integrity is maintained by the luminal redox status of the glutathione/glutathione disulfide (GSH/GSSG) and cysteine/cystine (Cys/CySS) couples which also support luminal nutrient absorption, mucus fluidity, and a diverse microbiota. The epithelial layer is uniquely organized for rapid self-renewal that is achieved by the well-regulated processes of crypt stem cell proliferation and crypt-to-villus cell differentiation. The GSH/GSSG and Cys/CySS redox couples, known to modulate intestinal cell transition through proliferation, differentiation or apoptosis, could govern the regenerative potential of the mucosa. These two couples, together with that of the thioredoxin/thioredoxin disulfide (Trx/TrxSS) couple are the major intracellular redox systems, and it is proposed that they each function as distinctive redox control nodes or circuitry in the control of metabolic processes and networks of enzymatic reactions. Specificity of redox signaling is accomplished in part by subcellular compartmentation of the individual redox systems within the mitochondria, nucleus, endoplasmic reticulum, and cytosol wherein each defined redox environment is suited to the specific metabolic function within that compartment. Mucosal oxidative stress would result from the disruption of these unique redox control nodes, and the subsequent alteration in redox signaling can contribute to the development of degenerative pathologies of the intestine, such as inflammation and cancer." @default.
- W1993463781 created "2016-06-24" @default.
- W1993463781 creator A5025879783 @default.
- W1993463781 creator A5055688197 @default.
- W1993463781 date "2012-09-01" @default.
- W1993463781 modified "2023-10-17" @default.
- W1993463781 title "Intestinal redox biology and oxidative stress" @default.
- W1993463781 cites W120058826 @default.
- W1993463781 cites W1505671001 @default.
- W1993463781 cites W1545965226 @default.
- W1993463781 cites W1568038787 @default.
- W1993463781 cites W1581565952 @default.
- W1993463781 cites W1586029261 @default.
- W1993463781 cites W1592601399 @default.
- W1993463781 cites W1836945052 @default.
- W1993463781 cites W1919062457 @default.
- W1993463781 cites W1923556669 @default.
- W1993463781 cites W1963876032 @default.
- W1993463781 cites W1968301448 @default.
- W1993463781 cites W1970240791 @default.
- W1993463781 cites W1977820789 @default.
- W1993463781 cites W1980023909 @default.
- W1993463781 cites W1980366492 @default.
- W1993463781 cites W1981977511 @default.
- W1993463781 cites W1982603620 @default.
- W1993463781 cites W1984502108 @default.
- W1993463781 cites W1987041278 @default.
- W1993463781 cites W1989329280 @default.
- W1993463781 cites W1991482163 @default.
- W1993463781 cites W1993851979 @default.
- W1993463781 cites W1995565650 @default.
- W1993463781 cites W1997836599 @default.
- W1993463781 cites W2000462205 @default.
- W1993463781 cites W2002176453 @default.
- W1993463781 cites W2002794726 @default.
- W1993463781 cites W2003424014 @default.
- W1993463781 cites W2003788503 @default.
- W1993463781 cites W2004814469 @default.
- W1993463781 cites W2006610864 @default.
- W1993463781 cites W2008755776 @default.
- W1993463781 cites W2009476974 @default.
- W1993463781 cites W2010749876 @default.
- W1993463781 cites W2012625102 @default.
- W1993463781 cites W2012751072 @default.
- W1993463781 cites W2012973235 @default.
- W1993463781 cites W2013414071 @default.
- W1993463781 cites W2015077792 @default.
- W1993463781 cites W2016901103 @default.
- W1993463781 cites W2022892655 @default.
- W1993463781 cites W2023196187 @default.
- W1993463781 cites W2024305069 @default.
- W1993463781 cites W2026465800 @default.
- W1993463781 cites W2026875029 @default.
- W1993463781 cites W2027020490 @default.
- W1993463781 cites W2028991058 @default.
- W1993463781 cites W2035461622 @default.
- W1993463781 cites W2036001773 @default.
- W1993463781 cites W2037176611 @default.
- W1993463781 cites W2038631870 @default.
- W1993463781 cites W2042549443 @default.
- W1993463781 cites W2045659794 @default.
- W1993463781 cites W2050612118 @default.
- W1993463781 cites W2051244361 @default.
- W1993463781 cites W2052969143 @default.
- W1993463781 cites W2053162975 @default.
- W1993463781 cites W2054598690 @default.
- W1993463781 cites W2056846026 @default.
- W1993463781 cites W2058748520 @default.
- W1993463781 cites W2061634271 @default.
- W1993463781 cites W2062321151 @default.
- W1993463781 cites W2062609826 @default.
- W1993463781 cites W2063860588 @default.
- W1993463781 cites W2064600250 @default.
- W1993463781 cites W2065463296 @default.
- W1993463781 cites W2066220808 @default.
- W1993463781 cites W2066415215 @default.
- W1993463781 cites W2067526109 @default.
- W1993463781 cites W2068894470 @default.
- W1993463781 cites W2069947580 @default.
- W1993463781 cites W2075697830 @default.
- W1993463781 cites W2077633497 @default.
- W1993463781 cites W2078591745 @default.
- W1993463781 cites W2080997681 @default.
- W1993463781 cites W2081471404 @default.
- W1993463781 cites W2082173679 @default.
- W1993463781 cites W2084108631 @default.
- W1993463781 cites W2084144603 @default.
- W1993463781 cites W2087434357 @default.
- W1993463781 cites W2088647063 @default.
- W1993463781 cites W2095219362 @default.
- W1993463781 cites W2095935706 @default.
- W1993463781 cites W2098278242 @default.
- W1993463781 cites W2099215206 @default.
- W1993463781 cites W2106896953 @default.
- W1993463781 cites W2113737673 @default.
- W1993463781 cites W2114915182 @default.
- W1993463781 cites W2116567644 @default.
- W1993463781 cites W2117612604 @default.