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• W1993465020 abstract "Virtually all biological processes rely on protein-protein interactions (PPIs) for signal propagation, therefore representing a vast array of potentially viable therapeutic intervention points. Targeting PPIs is a relatively novel drug development strategy so computational approaches towards analysing the interface between protein partners and predicting the likelihood of developing a small molecule inhibitor are still progressing. This review provides an overview of recent successful examples of computational methodologies used to predict druggable PPIs and small molecules designed to inhibit them." @default.
• W1993465020 created "2016-06-24" @default.
• W1993465020 creator A5066223674 @default.
• W1993465020 date "2013-12-01" @default.
• W1993465020 modified "2023-09-25" @default.
• W1993465020 title "De-peptidising protein–protein interactions – big jobs for small molecules" @default.
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• W1993465020 doi "https://doi.org/10.1016/j.ddtec.2013.08.002" @default.
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