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- W1993469356 abstract "pOSTOPERATIVE infection in the neurosurgical patient is a serious complication often resulting in fatal meningitis or brain abscess. Further major surgery is often required. The incidence of infections in neurosurgical cases is not much different from that in general surgery. Coagulase-positive staphylococci are the most common infecting organisms. Burke 1 has shown that antibiotics prevent soft tissue infections providing the drug is given within 3 hours of the bacterial inoculation. If there is a longer delay, the antibiotic loses its ability to prevent infection and merely modifies the subsequent course. These data indicate that if antibiotics are to prevent an infection, they must be available to kill the bacteria before a biochemical lesion has been established. Thus, there is a valuable period during which prevention of infection is possible. However, the established duration of this period in soft tissue infections may be exceeded by the appreciable time necessary to establish effective bactericidal concentrations in the cerebrospinal fluid. The statement that antibiotics do not penetrate the blood brain barrier is only a half truth since factors of time and concentration are usually neglected. Radioactively-tagged penicillin does enter the cerebrospinal fluid slowly, but high concentrations in the cerebrospinal fluid are not achieved because the penicillin is actively removed from the fluid by a mechanism analogous to secretion. 4 High blood concentrations do elevate cerebrospinal fluid levels. Trauma and inflammatory changes alter the permeability of vessels and favor the passage of antibiotics from the blood to the cerebrospinal fluid. Since even small traces of antibiotics influence the growth of bacteria, the efficacy of antibiotics in the prevention of infection" @default.
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- W1993469356 date "1968-01-01" @default.
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- W1993469356 title "Antibiotic Prevention of Experimental Staphylococcal Meningitis" @default.
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- W1993469356 doi "https://doi.org/10.3171/jns.1968.28.1.0045" @default.
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