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- W1993472912 abstract "GRAZ-01-16 Introduction: In contrast to necrosis, apoptosis represents a pattern of cell damage associated with an active intracellular death program. Recent data indicate that cardiac arrest is followed by neuronal apoptosis [1]. The aim of this study was to determine the effects of antiapoptotic baculovirus protein p35 on survival and neurological recovery following cardiac arrest. Methods: After approval by the animal care committee and in a randomized and blinded setting, cardio-circulatory arrest was induced in p35 transgenic rats and their non-transgenic littermates by electrical fibrillation of the heart. Following 6 min of cardiac arrest, cardio pulmonary resuscitation (CPR) was carried out as described previously [1]. After restoration of spontaneous circulation (ROSC), animals were allowed to survive for 7 days. At 24 h, 3 days, and 7 days after ROSC, animals were tested according to a neurological deficit score (NDS; 100 = worst; 0 = best [2]). Results: No differences between groups were observed with regard to weight, duration of CPR, body temperature, mean arterial pressure, and results of arterial blood-gas analyses. The rate of ROSC was higher in p35 transgenic animals (92%; n = 12/13) than in non transgenic controls (68%; n = 17/25; P = 0.09); and 85% (n = 11) of p35 transgenic animals survived for 7 days, as compared to 52% (n = 13) of controls (P < 0.05). A neurological recovery (worst NDS minus best NDS) below 30 was observed in 45% of transgenic animals and in 85% of non-transgenic animals (P = 0.055). Conclusions: Following 6 min of cardiac arrest, 7-day survival was significantly better in p35 transgenic animals than in non-transgenic controls. Therefore, antiapoptotic baculovirus protein p35 may play a role in postischaemic recovery following cardiac arrest." @default.
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- W1993472912 date "2002-03-01" @default.
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- W1993472912 title "Improved outcome after global cerebral ischaemia due to cardiocirculatory arrest in transgenic rats expressing baculovirus broad spectrum caspase inhibitor p35" @default.
- W1993472912 doi "https://doi.org/10.1097/00003643-200203000-00025" @default.
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