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• W1993473246 abstract "A ntigen isolated from I mmunoselected M elanoma-2 (AIM-2) was recently identified using melanoma-reactive CD8+ T cells. AIM-2 antigen is expressed in a wide variety of tumor types, including neuroectodermal tumors, as well as breast, ovarian and colon carcinomas. In this study, we analyzed AIM-2 expression in glioblastoma multiforme (GBM) in primary cultured cells and established GBM cell lines. We found that the primary GBM cell lines expressed 88.4% and 93.0% of non-spliced and spliced AIM-2, respectively. Five out of seven of the established GBM cell lines expressed both non-spliced and spliced AIM-2. Furthermore, the C9 CTL clone, which is specific for AIM-2 peptide (RSDSGQQARY), efficiently recognized GBM tumor cells in an antigen-specific and HLA-A1 restricted manner. IFN-γ treatment of the GBM tumor cells dramatically increased HLA-A1 expression levels and, consequently, increased CTL recognition of the treated tumor cells. More importantly, seven out of 12 HLA-A1 and AIM-2 positive patients from our dendritic cell clinical trial generated AIM-2 specific CTL activity in their PBMC after vaccinations. These data indicate that AIM-2 could be used as a tumor antigen target for monitoring vaccine trials or to develop antigen specific active immunotherapy for glioma patients." @default.
• W1993473246 created "2016-06-24" @default.
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• W1993473246 date "2004-01-01" @default.
• W1993473246 modified "2023-10-17" @default.
• W1993473246 title "AIM-2: A Novel Tumor Antigen is Expressed and Presented by Human Glioma Cells" @default.
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• W1993473246 doi "https://doi.org/10.1097/00002371-200405000-00006" @default.
• W1993473246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15076139" @default.
• W1993473246 hasPublicationYear "2004" @default.
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