FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993475456> ?p ?o ?g. }

• W1993475456 endingPage "781" @default.
• W1993475456 startingPage "769" @default.
• W1993475456 abstract "The time course and cellular basis for inflammation-induced hypertrophy of adipose tissue were investigated over 20 weeks in mature male rats. Mild inflammation was induced by subcutaneous injection of 20 microg lipopolysaccharide into one hind-leg three times/week for 4 or 8 weeks, followed by up to 12 weeks 'rest' without intervention. Mean volume and frequency of apoptosis (TUNEL assay) were measured in adipocytes isolated from sites defined by their anatomical relations to lymph nodes, plus numbers of CCL21-stimulated lymph node-derived and adipose tissue-derived dendritic cells. Experimental inflammation increased dendritic cells and adipocyte apoptosis in the locally stimulated popliteal depot and the lymphoid tissue-associated regions of the contralateral popliteal and mesentery and omentum. Responses declined slowly after inflammation ended, but all measurements from the locally stimulated popliteal depot, and the omentum, were still significantly different from controls after 12 weeks rest. The locally stimulated popliteal adipose tissue enlarged by 5% within 4 weeks and remained larger than the control. We conclude that prolonged inflammation induces permanent enlargement, greater adipocyte turnover and increased dendritic cell surveillance in the adjacent adipose tissue and the omentum. The experiment suggests a mechanism for selective hypertrophy of lymphoid tissue-associated adipose tissue in chronic stress and inflammatory disorders, including impaired lymph drainage, Crohn's disease and HIV-associated lipodystrophy, and a link between evolutionary fitness, sexual selection and aesthetically pleasing body symmetry. It would be useful for further study of molecular mechanisms in inflammation-induced local hypertrophy of adipose tissue and development of specific therapies that avoid interference with whole-body lipid metabolism." @default.
• W1993475456 created "2016-06-24" @default.
• W1993475456 creator A5049507397 @default.
• W1993475456 creator A5069828459 @default.
• W1993475456 creator A5084007365 @default.
• W1993475456 date "2005-12-01" @default.
• W1993475456 modified "2023-10-10" @default.
• W1993475456 title "Changes in adipocytes and dendritic cells in lymph node containing adipose depots during and after many weeks of mild inflammation" @default.
• W1993475456 cites W1485708225 @default.
• W1993475456 cites W1507807725 @default.
• W1993475456 cites W1924240621 @default.
• W1993475456 cites W1943105996 @default.
• W1993475456 cites W1954333522 @default.
• W1993475456 cites W1963504546 @default.
• W1993475456 cites W1965168543 @default.
• W1993475456 cites W1966847558 @default.
• W1993475456 cites W1967166375 @default.
• W1993475456 cites W1967466043 @default.
• W1993475456 cites W1969408132 @default.
• W1993475456 cites W1972621450 @default.
• W1993475456 cites W1978725428 @default.
• W1993475456 cites W1980481859 @default.
• W1993475456 cites W1981444005 @default.
• W1993475456 cites W1984900499 @default.
• W1993475456 cites W1987189896 @default.
• W1993475456 cites W1987406457 @default.
• W1993475456 cites W1998856849 @default.
• W1993475456 cites W2004637990 @default.
• W1993475456 cites W2008869160 @default.
• W1993475456 cites W2013219143 @default.
• W1993475456 cites W2015285622 @default.
• W1993475456 cites W2025402259 @default.
• W1993475456 cites W2038895942 @default.
• W1993475456 cites W2043544754 @default.
• W1993475456 cites W2044561304 @default.
• W1993475456 cites W2051595621 @default.
• W1993475456 cites W2053147934 @default.
• W1993475456 cites W2053961730 @default.
• W1993475456 cites W2056469345 @default.
• W1993475456 cites W2059511498 @default.
• W1993475456 cites W2064119981 @default.
• W1993475456 cites W2076633494 @default.
• W1993475456 cites W2081931036 @default.
• W1993475456 cites W2082823021 @default.
• W1993475456 cites W2092746889 @default.
• W1993475456 cites W2093888746 @default.
• W1993475456 cites W2094317193 @default.
• W1993475456 cites W2104962128 @default.
• W1993475456 cites W2105954474 @default.
• W1993475456 cites W2106467350 @default.
• W1993475456 cites W2106919150 @default.
• W1993475456 cites W2120381143 @default.
• W1993475456 cites W2121458223 @default.
• W1993475456 cites W2122506498 @default.
• W1993475456 cites W2130764919 @default.
• W1993475456 cites W2149319343 @default.
• W1993475456 cites W2155439405 @default.
• W1993475456 cites W2158079900 @default.
• W1993475456 cites W2164019905 @default.
• W1993475456 cites W2167456107 @default.
• W1993475456 cites W2336356651 @default.
• W1993475456 cites W2337269445 @default.
• W1993475456 cites W2340325420 @default.
• W1993475456 cites W2400452835 @default.
• W1993475456 cites W2415166349 @default.
• W1993475456 cites W4245383502 @default.
• W1993475456 cites W4249727000 @default.
• W1993475456 doi "https://doi.org/10.1111/j.1469-7580.2005.00506.x" @default.
• W1993475456 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1571578" @default.
• W1993475456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16367804" @default.
• W1993475456 hasPublicationYear "2005" @default.
• W1993475456 type Work @default.
• W1993475456 sameAs 1993475456 @default.
• W1993475456 citedByCount "39" @default.
• W1993475456 countsByYear W19934754562012 @default.
• W1993475456 countsByYear W19934754562013 @default.
• W1993475456 countsByYear W19934754562014 @default.
• W1993475456 countsByYear W19934754562015 @default.
• W1993475456 countsByYear W19934754562016 @default.
• W1993475456 countsByYear W19934754562017 @default.
• W1993475456 countsByYear W19934754562018 @default.
• W1993475456 countsByYear W19934754562019 @default.
• W1993475456 countsByYear W19934754562020 @default.
• W1993475456 countsByYear W19934754562021 @default.
• W1993475456 countsByYear W19934754562022 @default.
• W1993475456 crossrefType "journal-article" @default.
• W1993475456 hasAuthorship W1993475456A5049507397 @default.
• W1993475456 hasAuthorship W1993475456A5069828459 @default.
• W1993475456 hasAuthorship W1993475456A5084007365 @default.
• W1993475456 hasBestOaLocation W19934754561 @default.
• W1993475456 hasConcept C126322002 @default.
• W1993475456 hasConcept C134018914 @default.
• W1993475456 hasConcept C142724271 @default.
• W1993475456 hasConcept C167414201 @default.
• W1993475456 hasConcept C171089720 @default.
• W1993475456 hasConcept C181152851 @default.
• W1993475456 hasConcept C2776175234 @default.
• W1993475456 hasConcept C2776914184 @default.

• next