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• W1993476523 abstract "No AccessJournal of UrologyInvestigative Urology1 Feb 1999MEASUREMENT OF INTERCELLULAR ELECTRICAL COUPLING IN GUINEA-PIG DETRUSOR SMOOTH MUSCLE C.H. FRY, M. COOKLIN, J. BIRNS, and A.R. MUNDY C.H. FRYC.H. FRY More articles by this author , M. COOKLINM. COOKLIN More articles by this author , J. BIRNSJ. BIRNS More articles by this author , and A.R. MUNDYA.R. MUNDY More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)61990-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The electrical impedance of detrusor smooth muscle strips to alternating current has been measured to calculate the resistance of the intracellular pathway, in particular gap junction resistance. Values have been compared with myocardium, which is electrically well-coupled. Materials and Methods: Alternating current was passed along the intracellular pathway of muscle strips by creating a high extracellular resistance around the preparation. The data were analyzed in terms of an equivalent circuit consisting of an intracellular and extracellular pathway. Results: Intracellular resistance was divided into two series components, a cytoplasmic resistance and a gap junction resistance. Detrusor intracellular resistance was about three times that of myocardium. The greater value was attributed to a larger gap-junction resistance. Superfusion of detrusor strips with an isosmotic solution of 50% sucrose, 50% Tyrode's increased both cytoplasm and gap junction resistances. Conclusions: Gap-junction resistance is larger in detrusor compared with myocardium. However, significant electrical current can still pass between adjacent detrusor cells. Calculation of the space constant however shows that functionally detrusor is electrically well-coupled because of the high membrane resistance. The functional consequences of these findings are discussed. References 1 : Structural basis of geriatric voiding dysfunction, II. Ageing detrusor: normal versus impaired contractility. J. Urol.1993; 150: 1657. Abstract, Google Scholar 2 : Electrical properties of smooth muscle in the guinea-pig urinary bladder. J. Physiol.1996; 492: 185. Google Scholar 3 : The effect of experimental urethral obstruction and its reversal on changes in passive electrical properties of detrusor muscle. J. Urol.1992; 148: 1957. Abstract, Google Scholar 4 : Cable properties of smooth muscle. J. Physiol.1968; 196: 87. Google Scholar 5 : Changes in cell-to-cell electrical coupling associated with left ventricular hypertrophy. Circ. Res.1997; 80: 765. Google Scholar 6 : An analysis of the cable properties of frog ventricular myocardium. J. Physiol.1978; 283: 263. Google Scholar 7 : The structural implications of the linear electrical properties of cardiac Purkinje strands. J. Gen. Physiol.1970; 55: 524. Google Scholar 8 : Determination of biological impedances. In: . New York & London: Academic Press1966. Google Scholar 9 : Membrane currents of cultured smooth muscle cells of guinea-pig urinary bladder. J. Physiol.1997; 501: 111P. Google Scholar 10 : Magnesium affects excitation, conduction and contraction of isolated mammalian cardiac muscle. Am. J. Physiol.1992; 263: H622. Google Scholar 11 : Oxford: Clarendon Press1976. Google Scholar 12 : Exponential activation of the cardiac Na+ current in single guinea-pig ventricular cells. J. Physiol.1992; 453: 261. Google Scholar 13 : The actions of extracellular H+ on the electro-physiological properties of isolated human detrusor smooth muscle cells. J. Physiol.1994; 480: 71. Google Scholar 14 : Intracellular studies of electrical membrane properties of opossum esophageal circular smooth muscle. Gastroenterology1987; 92: 987. Google Scholar 15 : Effects of various osmotic solutions on membrane properties of smooth muscle cells of guinea-pig ureter. Invest. Urol.1981; 19: 79. Google Scholar From the Institute of Urology and Nephrology, London, United Kingdom(FRY) Requests for reprints: Institute of Urology and Nephrology, 67 Riding House Street, London W1P 7PN, United Kingdom.We thank the Wellcome Trust, British Heart Foundation and Action Research for financial assistance.© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited bySUI G, WU C and FRY C (2018) Electrical Characteristics of Suburothelial Cells Isolated From the Human BladderJournal of Urology, VOL. 171, NO. 2, (938-943), Online publication date: 1-Feb-2004.SUI G, WU C and FRY C (2018) THE ELECTROPHYSIOLOGICAL PROPERTIES OF CULTURED AND FRESHLY ISOLATED DETRUSOR SMOOTH MUSCLE CELLSJournal of Urology, VOL. 165, NO. 2, (627-632), Online publication date: 1-Feb-2001.SUI G, WU C and FRY C (2018) INWARD CALCIUM CURRENTS IN CULTURED AND FRESHLY ISOLATED DETRUSOR MUSCLE CELLS: : EVIDENCE OF A T-TYPE CALCIUM CURRENTJournal of Urology, VOL. 165, NO. 2, (621-626), Online publication date: 1-Feb-2001. Volume 161Issue 2February 1999Page: 660-664 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.MetricsAuthor Information C.H. FRY More articles by this author M. COOKLIN More articles by this author J. BIRNS More articles by this author A.R. MUNDY More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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