FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993480904> ?p ?o ?g. }

• W1993480904 abstract "Voltage-gated sodium (Nav) channels are required for impulse conductance in excitable tissues. Navs have been linked to human cancers, including prostate. The expression and distribution of Nav isoforms (Nav1.1-Nav1.9) in human prostate cancer are not well established. Here, we evaluated the expression of these isoforms and investigated the expression of Nav1.8 in human prostate cancer tissues. Nav1.8 was highly expressed in all examined cells. Expression of Nav1.1, Nav1.2, and Nav1.9 were high in DU-145, PC-3 and PC-3M cells compared to LNCaP (hormonedependent), C4-2, C4-2B, and CWR22Rv-1 cells. Nav1.5 and Nav1.6 were expressed in all cells examined. Nav1.7 expression was absent in PC-3M and CWR22Rv-1, but expressed in the other cells examined. Immunohistochemistry revealed intensive Nav1.8 staining correlated with more advanced pathologic stage of disease. Increased intensity of nuclear Nav1.8 correlated with increased Gleason grade. Our results revealed that Nav1.8 is universally expressed in human prostate cancer cells. Nav1.8 expression statistically correlated with pathologic stage (P=0.04) and Gleason score (P=0.01) of human prostate tissue specimens. The aberrant nuclear localization of Nav1.8 with advanced prostate cancer tissues warrant further investigation into use of Nav1.8 as a potential biomarker to differentiate between early and advanced disease." @default.
• W1993480904 created "2016-06-24" @default.
• W1993480904 creator A5006850280 @default.
• W1993480904 creator A5008537300 @default.
• W1993480904 creator A5010153046 @default.
• W1993480904 creator A5011752239 @default.
• W1993480904 creator A5012359411 @default.
• W1993480904 creator A5019326307 @default.
• W1993480904 creator A5042973046 @default.
• W1993480904 creator A5054919553 @default.
• W1993480904 creator A5056302482 @default.
• W1993480904 creator A5063506311 @default.
• W1993480904 date "2012-01-01" @default.
• W1993480904 modified "2023-10-17" @default.
• W1993480904 title "Expression of Voltage-Gated Sodium Channel Nav1.8 in Human Prostate Cancer is Associated with High Histological Grade" @default.
• W1993480904 cites W1974436639 @default.
• W1993480904 cites W1975169327 @default.
• W1993480904 cites W1983602021 @default.
• W1993480904 cites W1986948721 @default.
• W1993480904 cites W1990116234 @default.
• W1993480904 cites W1990133698 @default.
• W1993480904 cites W1991813803 @default.
• W1993480904 cites W2003852222 @default.
• W1993480904 cites W2024711707 @default.
• W1993480904 cites W2043103956 @default.
• W1993480904 cites W2080948706 @default.
• W1993480904 cites W2083839003 @default.
• W1993480904 cites W2114016572 @default.
• W1993480904 cites W2124298637 @default.
• W1993480904 cites W2127372741 @default.
• W1993480904 cites W2143125286 @default.
• W1993480904 cites W2165122774 @default.
• W1993480904 cites W2167798890 @default.
• W1993480904 cites W25735620 @default.
• W1993480904 cites W54255267 @default.
• W1993480904 doi "https://doi.org/10.4172/2324-9110.1000102" @default.
• W1993480904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3807742" @default.
• W1993480904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24163825" @default.
• W1993480904 hasPublicationYear "2012" @default.
• W1993480904 type Work @default.
• W1993480904 sameAs 1993480904 @default.
• W1993480904 citedByCount "19" @default.
• W1993480904 countsByYear W19934809042015 @default.
• W1993480904 countsByYear W19934809042016 @default.
• W1993480904 countsByYear W19934809042017 @default.
• W1993480904 countsByYear W19934809042018 @default.
• W1993480904 countsByYear W19934809042019 @default.
• W1993480904 countsByYear W19934809042020 @default.
• W1993480904 countsByYear W19934809042021 @default.
• W1993480904 countsByYear W19934809042022 @default.
• W1993480904 countsByYear W19934809042023 @default.
• W1993480904 crossrefType "journal-article" @default.
• W1993480904 hasAuthorship W1993480904A5006850280 @default.
• W1993480904 hasAuthorship W1993480904A5008537300 @default.
• W1993480904 hasAuthorship W1993480904A5010153046 @default.
• W1993480904 hasAuthorship W1993480904A5011752239 @default.
• W1993480904 hasAuthorship W1993480904A5012359411 @default.
• W1993480904 hasAuthorship W1993480904A5019326307 @default.
• W1993480904 hasAuthorship W1993480904A5042973046 @default.
• W1993480904 hasAuthorship W1993480904A5054919553 @default.
• W1993480904 hasAuthorship W1993480904A5056302482 @default.
• W1993480904 hasAuthorship W1993480904A5063506311 @default.
• W1993480904 hasBestOaLocation W19934809042 @default.
• W1993480904 hasConcept C104317684 @default.
• W1993480904 hasConcept C121608353 @default.
• W1993480904 hasConcept C126322002 @default.
• W1993480904 hasConcept C142724271 @default.
• W1993480904 hasConcept C178790620 @default.
• W1993480904 hasConcept C185592680 @default.
• W1993480904 hasConcept C204232928 @default.
• W1993480904 hasConcept C2776235491 @default.
• W1993480904 hasConcept C2777589315 @default.
• W1993480904 hasConcept C2779723316 @default.
• W1993480904 hasConcept C2780192828 @default.
• W1993480904 hasConcept C502942594 @default.
• W1993480904 hasConcept C50952357 @default.
• W1993480904 hasConcept C53345823 @default.
• W1993480904 hasConcept C537181965 @default.
• W1993480904 hasConcept C55493867 @default.
• W1993480904 hasConcept C71924100 @default.
• W1993480904 hasConcept C86803240 @default.
• W1993480904 hasConcept C87874733 @default.
• W1993480904 hasConceptScore W1993480904C104317684 @default.
• W1993480904 hasConceptScore W1993480904C121608353 @default.
• W1993480904 hasConceptScore W1993480904C126322002 @default.
• W1993480904 hasConceptScore W1993480904C142724271 @default.
• W1993480904 hasConceptScore W1993480904C178790620 @default.
• W1993480904 hasConceptScore W1993480904C185592680 @default.
• W1993480904 hasConceptScore W1993480904C204232928 @default.
• W1993480904 hasConceptScore W1993480904C2776235491 @default.
• W1993480904 hasConceptScore W1993480904C2777589315 @default.
• W1993480904 hasConceptScore W1993480904C2779723316 @default.
• W1993480904 hasConceptScore W1993480904C2780192828 @default.
• W1993480904 hasConceptScore W1993480904C502942594 @default.
• W1993480904 hasConceptScore W1993480904C50952357 @default.
• W1993480904 hasConceptScore W1993480904C53345823 @default.
• W1993480904 hasConceptScore W1993480904C537181965 @default.
• W1993480904 hasConceptScore W1993480904C55493867 @default.
• W1993480904 hasConceptScore W1993480904C71924100 @default.
• W1993480904 hasConceptScore W1993480904C86803240 @default.

• next