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- W1993481071 abstract "Following incubation with activated neutrophils, two metabolites of 5-aminosalicyclic acid (5-ASA) were identified by HPLC. These two metabolites accounted for approximately 60% and 20% of the original 5-ASA. The formation of the major metabolite was prevented by pre-incubation with the peroxidase inhibitor, azide, and reduced by the omission of chloride ions from the incubation medium, or the presence of catalase. A similar product was generated by sodium hypochlorite or myeloperoxidase/H2O2, mass spectroscopical analysis being consistent with it being 5-nitroso-salicylate. Our finding suggests that the efficacy of 5-ASA results from its ability to react with and so scavenge hypochlorite ions. The amount of amine-modified 5-ASA in the faecal stream may thus provide an indicator for hypochlorite production in the bowel." @default.
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- W1993481071 date "1991-10-01" @default.
- W1993481071 modified "2023-09-25" @default.
- W1993481071 title "The production of an amine-modified derivative of 5-aminosalicylic acid by activated neutrophils Roles for myeloperoxidase and chloride ions" @default.
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- W1993481071 doi "https://doi.org/10.1016/0006-2952(91)90583-q" @default.
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