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- W1993485378 abstract "A ubiquitously employed mechanism for signal transduction involves ligand binding to a cell surface receptor coupled to a heterotrimeric guanine nucleotide-binding protein (G protein). Receptor activation stimulates nucleotide exchange and dissociation of the G protein, releasing the Gα subunit in its GTP-bound state from the Gβγ complex. The released subunits can stimulate a variety of target (effector) enzymes (1), thereby eliciting biochemical responses and changes in cellular physiology. Hundreds of G protein-coupled receptors have been identified (2, 3)." @default.
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- W1993485378 date "1997-02-01" @default.
- W1993485378 modified "2023-10-15" @default.
- W1993485378 title "RGS Proteins and Signaling by Heterotrimeric G Proteins" @default.
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- W1993485378 doi "https://doi.org/10.1074/jbc.272.7.3871" @default.
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