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- W1993497504 abstract "The Runx transcription factors are essential for mammalian development, most notably in the haematopoietic and osteogenic lineages. Runx1 and its binding partner, CBFβ, are frequently targeted in acute leukaemia but evidence is accumulating that all three Runx genes may have a role to play in a wider range of cancers, either as tumour promoters or tumour suppressors. Whilst Runx2 is renowned for its role as a master regulator of bone development we discuss here its expression pattern and putative functions beyond this lineage. Furthermore, we review the evidence that RUNX2 promotes neoplastic development in haematopoietic lineages and in advanced mammary and prostate cancer." @default.
- W1993497504 created "2016-06-24" @default.
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- W1993497504 date "2010-08-01" @default.
- W1993497504 modified "2023-10-17" @default.
- W1993497504 title "Runx2 in normal tissues and cancer cells: A developing story" @default.
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- W1993497504 doi "https://doi.org/10.1016/j.bcmd.2010.05.007" @default.
- W1993497504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20580290" @default.
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