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- W1993504891 abstract "Abstract In an attempt to clarify how cells integrate the signals provided by multiple chemokines expressed during inflammation, we have uncovered a novel mechanism regulating leukocyte trafficking. Our data indicate that the concomitant exposure to CCR4 agonists and CXCL10/IP‐10 strongly enhances the chemotactic response of human T lymphocytes. This enhancement is synergistic rather than additive and occurs via CCR4 since it persists after CXCR3 blockade. Besides chemotaxis, other cellular responses are enhanced upon stimulation of CCR4‐transfected cells with CCL22/MDC plus CXCL10. Several other chemokines in addition to CXCL10 were able to increase CCL22‐mediated chemotaxis. The first β‐strand of the chemokine structure is highly and specifically implicated in this phenomenon, as established using synergy‐inducing and non‐synergy‐inducing chimeric chemokines. As shown in situ for skin from atopic and allergic contact dermatitis patients, this organ becomes the ideal environment in which skin‐homing CCR4 + T lymphocytes can accumulate under the stimulus offered by CCR4 agonists, together with the synergistic chemokines that are concomitantly expressed. Overall, our results indicate that chemokine‐induced synergism strengthens leukocyte recruitment towards tissues co‐expressing several chemokines." @default.
- W1993504891 created "2016-06-24" @default.
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- W1993504891 date "2005-02-22" @default.
- W1993504891 modified "2023-10-11" @default.
- W1993504891 title "CCL22-induced responses are powerfully enhanced by synergy inducing chemokines via CCR4: evidence for the involvement of first ?-strand of chemokine" @default.
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- W1993504891 doi "https://doi.org/10.1002/eji.200525800" @default.
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