FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993508059> ?p ?o ?g. }

• W1993508059 endingPage "382" @default.
• W1993508059 startingPage "374" @default.
• W1993508059 abstract "Opioids and clonidine, used in for sedation, analgesia and control of opioid withdrawal in neonates, directly or indirectly activate opioid receptors (OPRs) expressed in immune cells. Therefore, our objective is to study how clinically relevant concentrations of different opioids and clonidine change cytokine levels in cultured whole blood from preterm and full-term infants.Using blood from preterm (≤ 30 weeks gestational age (GA), n=7) and full-term ( ≥ 37 weeks GA, n=19) infants, we investigated the changes in cytokine profile (IL-1β, IL-6, IL-8, IL-10, IL-12p70 and TNF-α), cyclic adenosine monophosphate (cAMP) levels and μ-, δ- and κ- opioid receptor (OPR) gene and protein expression, following in-vitro exposure to morphine, methadone, fentanyl or clonidine at increasing concentrations ranging from 0 to 1 mM.Following lipopolysaccharide activation, IL-10 levels were 146-fold greater in cultured blood from full-term than from preterm infants. Morphine and methadone, but not fentanyl, at >10(-5) M decreased all tested cytokines except IL-8. In contrast, clonidine at <10(-9) M increased IL-6, while at >10(-5) M increased IL-1β and decreased TNF-α levels. All cytokine changes followed the same patterns in preterm and full-term infant cultured blood and matched increases in cAMP levels. All three μ-, δ- and κ-OPR genes were expressed in mononuclear cells (MNC) from preterm and full-term infants. Morphine, methadone and clonidine, but not fentanyl, at >10(-5)M decreased the expression of μ-OPR, but not δ- or κ-OPRs.Generalized cytokine suppression along with downregulation of μ-OPR expression observed in neonatal MNC exposed to morphine and methadone at clinically relevant concentrations contrast with the modest effects observed with fentanyl and clonidine. Therefore, we speculate that fentanyl and clonidine may be safer therapeutic choices for sedation and control of opioid withdrawal and pain in neonates." @default.
• W1993508059 created "2016-06-24" @default.
• W1993508059 creator A5008209961 @default.
• W1993508059 creator A5013838174 @default.
• W1993508059 creator A5015110301 @default.
• W1993508059 creator A5071248180 @default.
• W1993508059 creator A5083291881 @default.
• W1993508059 creator A5087128759 @default.
• W1993508059 date "2012-10-04" @default.
• W1993508059 modified "2023-10-15" @default.
• W1993508059 title "Opioids and clonidine modulate cytokine production and opioid receptor expression in neonatal immune cells" @default.
• W1993508059 cites W1897551156 @default.
• W1993508059 cites W1935962209 @default.
• W1993508059 cites W1972338761 @default.
• W1993508059 cites W1974252742 @default.
• W1993508059 cites W1975933847 @default.
• W1993508059 cites W1979097034 @default.
• W1993508059 cites W1979774071 @default.
• W1993508059 cites W1984111607 @default.
• W1993508059 cites W1989287758 @default.
• W1993508059 cites W1993711260 @default.
• W1993508059 cites W1995707689 @default.
• W1993508059 cites W199781670 @default.
• W1993508059 cites W2001883479 @default.
• W1993508059 cites W2002915058 @default.
• W1993508059 cites W2014176337 @default.
• W1993508059 cites W2014692323 @default.
• W1993508059 cites W2016987788 @default.
• W1993508059 cites W2018728735 @default.
• W1993508059 cites W2025202822 @default.
• W1993508059 cites W2025580438 @default.
• W1993508059 cites W2025951799 @default.
• W1993508059 cites W2029005597 @default.
• W1993508059 cites W2033852796 @default.
• W1993508059 cites W2036345864 @default.
• W1993508059 cites W2037659951 @default.
• W1993508059 cites W2040457846 @default.
• W1993508059 cites W2052143676 @default.
• W1993508059 cites W2053771766 @default.
• W1993508059 cites W2056535910 @default.
• W1993508059 cites W2056821819 @default.
• W1993508059 cites W2057532615 @default.
• W1993508059 cites W2057794769 @default.
• W1993508059 cites W2065709938 @default.
• W1993508059 cites W2066068520 @default.
• W1993508059 cites W2066524095 @default.
• W1993508059 cites W2068640384 @default.
• W1993508059 cites W2074291836 @default.
• W1993508059 cites W2075584722 @default.
• W1993508059 cites W2076276989 @default.
• W1993508059 cites W2079283237 @default.
• W1993508059 cites W2079577709 @default.
• W1993508059 cites W2084520505 @default.
• W1993508059 cites W2093049658 @default.
• W1993508059 cites W2094224794 @default.
• W1993508059 cites W2098568602 @default.
• W1993508059 cites W2099249565 @default.
• W1993508059 cites W2111584592 @default.
• W1993508059 cites W2115628342 @default.
• W1993508059 cites W2126228551 @default.
• W1993508059 cites W2131590129 @default.
• W1993508059 cites W2140212933 @default.
• W1993508059 cites W2140872638 @default.
• W1993508059 cites W2148491638 @default.
• W1993508059 cites W2153211079 @default.
• W1993508059 cites W2154634960 @default.
• W1993508059 cites W2160832823 @default.
• W1993508059 cites W2166866341 @default.
• W1993508059 cites W2167105661 @default.
• W1993508059 cites W4238102997 @default.
• W1993508059 cites W4250846564 @default.
• W1993508059 cites W4255160915 @default.
• W1993508059 cites W4293247451 @default.
• W1993508059 doi "https://doi.org/10.1038/jp.2012.124" @default.
• W1993508059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3640758" @default.
• W1993508059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23047422" @default.
• W1993508059 hasPublicationYear "2012" @default.
• W1993508059 type Work @default.
• W1993508059 sameAs 1993508059 @default.
• W1993508059 citedByCount "19" @default.
• W1993508059 countsByYear W19935080592014 @default.
• W1993508059 countsByYear W19935080592015 @default.
• W1993508059 countsByYear W19935080592016 @default.
• W1993508059 countsByYear W19935080592017 @default.
• W1993508059 countsByYear W19935080592018 @default.
• W1993508059 countsByYear W19935080592019 @default.
• W1993508059 countsByYear W19935080592021 @default.
• W1993508059 countsByYear W19935080592022 @default.
• W1993508059 countsByYear W19935080592023 @default.
• W1993508059 crossrefType "journal-article" @default.
• W1993508059 hasAuthorship W1993508059A5008209961 @default.
• W1993508059 hasAuthorship W1993508059A5013838174 @default.
• W1993508059 hasAuthorship W1993508059A5015110301 @default.
• W1993508059 hasAuthorship W1993508059A5071248180 @default.
• W1993508059 hasAuthorship W1993508059A5083291881 @default.
• W1993508059 hasAuthorship W1993508059A5087128759 @default.
• W1993508059 hasBestOaLocation W19935080592 @default.
• W1993508059 hasConcept C126322002 @default.

• next