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- W1993525572 abstract "Routine whole-breast radiotherapy comprises 50 Gy in daily fractions for 5 weeks. 1 Early Breast Cancer Trialists' Collaborative Group (EBCTCG)Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15–year survival: an overview of the randomised trials. Lancet. 2005; 366: 2087-2106 Summary Full Text Full Text PDF PubMed Scopus (3949) Google Scholar The additional application of an external boost of 10–16 Gy to the tumour bed leads to excellent local tumour control, with local recurrence rates around 6% after a median of 10-years' follow-up. 2 Bartelink H Horiot JC Poortmans PM et al. Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10–year results of the randomized boost versus no boost EORTC 22881-10882 trial. J Clin Oncol. 2007; 25: 3259-3265 Crossref PubMed Scopus (817) Google Scholar However, in view of the low and focal local recurrence rates, the concept of accelerated partial-breast irradiation has gained widespread interest with various methods. Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trialFor selected patients with early breast cancer, a single dose of radiotherapy delivered at the time of surgery by use of targeted intraoperative radiotherapy should be considered as an alternative to external beam radiotherapy delivered over several weeks. Full-Text PDF Open AccessDepartment of ErrorAzria D, Bourgier C. Partial breast irradiation: new standard for selected patients. Lancet 2010; published online June 5. DOI:10.1016/S0140-6736(10)60898-7—In this Comment, the third sentence of paragraph 3 should have read: “For instance, a dose of 15 Gy prescribed at 2 mm with a typical applicator of 3·5 cm diameter will deliver 10·6 Gy at a depth of 5 mm.” This correction has been made to the online version as of June 8, and also to the printed Comment. Full-Text PDF" @default.
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- W1993525572 title "Partial breast irradiation: new standard for selected patients" @default.
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