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• W1993539567 abstract "Among 2258 Helicobacter pylori –seropositive subjects randomly assigned to receive one-time H. pylori treatment with amoxicillin-omeprazole or its placebo, we evaluated the 15-year effect of treatment on gastric cancer incidence and mortality in subgroups defined by age, baseline gastric histopathology, and post-treatment infection status. We used conditional logistic and Cox regressions for covariable adjustments in incidence and mortality analyses, respectively. Treatment was associated with a statistically significant decrease in gastric cancer incidence (odds ratio = 0.36; 95% confidence interval [CI] = 0.17 to 0.79) and mortality (hazard ratio = 0.26; 95% CI = 0.09 to 0.79) at ages 55 years and older and a statistically significant decrease in incidence among those with intestinal metaplasia or dysplasia at baseline (odds ratio = 0.56; 95% CI = 0.34 to 0.91). Treatment benefits for incidence and mortality among those with and without post-treatment infection were similar. Thus H. pylori treatment can benefit older members and those with advanced baseline histopathology, and benefits are present even with post-treatment infection, suggesting treatment can benefit an entire population, not just the young or those with mild histopathology." @default.
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• W1993539567 date "2014-06-01" @default.
• W1993539567 modified "2023-10-17" @default.
• W1993539567 title "Effects of Helicobacter pylori Treatment on Gastric Cancer Incidence and Mortality in Subgroups" @default.
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• W1993539567 doi "https://doi.org/10.1093/jnci/dju116" @default.
• W1993539567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4067110" @default.
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