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• W1993543997 endingPage "e1000878" @default.
• W1993543997 startingPage "e1000878" @default.
• W1993543997 abstract "p53 can serve as a paradigm in studies aiming to figure out how allosteric perturbations in transcription factors (TFs) triggered by small changes in DNA response element (RE) sequences, can spell selectivity in co-factor recruitment. p53-REs are 20-base pair (bp) DNA segments specifying diverse functions. They may be located near the transcription start sites or thousands of bps away in the genome. Their number has been estimated to be in the thousands, and they all share a common motif. A key question is then how does the p53 protein recognize a particular p53-RE sequence among all the similar ones? Here, representative p53-REs regulating diverse functions including cell cycle arrest, DNA repair, and apoptosis were simulated in explicit solvent. Among the major interactions between p53 and its REs involving Lys120, Arg280 and Arg248, the bps interacting with Lys120 vary while the interacting partners of other residues are less so. We observe that each p53-RE quarter site sequence has a unique pattern of interactions with p53 Lys120. The allosteric, DNA sequence-induced conformational and dynamic changes of the altered Lys120 interactions are amplified by the perturbation of other p53-DNA interactions. The combined subtle RE sequence-specific allosteric effects propagate in the p53 and in the DNA. The resulting amplified allosteric effects far away are reflected in changes in the overall p53 organization and in the p53 surface topology and residue fluctuations which play key roles in selective co-factor recruitment. As such, these observations suggest how similar p53-RE sequences can spell the preferred co-factor binding, which is the key to the selective gene transactivation and consequently different functional effects." @default.
• W1993543997 created "2016-06-24" @default.
• W1993543997 creator A5007480448 @default.
• W1993543997 creator A5025357844 @default.
• W1993543997 date "2010-08-05" @default.
• W1993543997 modified "2023-10-16" @default.
• W1993543997 title "Lysine120 Interactions with p53 Response Elements can Allosterically Direct p53 Organization" @default.
• W1993543997 cites W1903324674 @default.
• W1993543997 cites W1924632885 @default.
• W1993543997 cites W1964719993 @default.
• W1993543997 cites W1965076207 @default.
• W1993543997 cites W1966082941 @default.
• W1993543997 cites W1971966311 @default.
• W1993543997 cites W1976010548 @default.
• W1993543997 cites W1976499671 @default.
• W1993543997 cites W1977108713 @default.
• W1993543997 cites W1978689426 @default.
• W1993543997 cites W1980749266 @default.
• W1993543997 cites W1989365013 @default.
• W1993543997 cites W1997641930 @default.
• W1993543997 cites W2000511163 @default.
• W1993543997 cites W2010204279 @default.
• W1993543997 cites W2011644641 @default.
• W1993543997 cites W2012299511 @default.
• W1993543997 cites W2020808779 @default.
• W1993543997 cites W2022395375 @default.
• W1993543997 cites W2024964669 @default.
• W1993543997 cites W2025919590 @default.
• W1993543997 cites W2026671371 @default.
• W1993543997 cites W2027408247 @default.
• W1993543997 cites W2029375121 @default.
• W1993543997 cites W2030914006 @default.
• W1993543997 cites W2032195954 @default.
• W1993543997 cites W2033855447 @default.
• W1993543997 cites W2033893364 @default.
• W1993543997 cites W2034562270 @default.
• W1993543997 cites W2035462635 @default.
• W1993543997 cites W2036651483 @default.
• W1993543997 cites W2038689662 @default.
• W1993543997 cites W2039013619 @default.
• W1993543997 cites W2043730018 @default.
• W1993543997 cites W2045143386 @default.
• W1993543997 cites W2049682677 @default.
• W1993543997 cites W2049945082 @default.
• W1993543997 cites W2050516993 @default.
• W1993543997 cites W2051210433 @default.
• W1993543997 cites W2053462331 @default.
• W1993543997 cites W2066962978 @default.
• W1993543997 cites W2067510722 @default.
• W1993543997 cites W2074222004 @default.
• W1993543997 cites W2079328211 @default.
• W1993543997 cites W2080413331 @default.
• W1993543997 cites W2080900378 @default.
• W1993543997 cites W2083975423 @default.
• W1993543997 cites W2087115003 @default.
• W1993543997 cites W2094375196 @default.
• W1993543997 cites W2095420958 @default.
• W1993543997 cites W2096276671 @default.
• W1993543997 cites W2108775001 @default.
• W1993543997 cites W2115152262 @default.
• W1993543997 cites W2115947396 @default.
• W1993543997 cites W2119742986 @default.
• W1993543997 cites W2121288046 @default.
• W1993543997 cites W2125218936 @default.
• W1993543997 cites W2126189696 @default.
• W1993543997 cites W2127085694 @default.
• W1993543997 cites W2129660964 @default.
• W1993543997 cites W2130885391 @default.
• W1993543997 cites W2131181464 @default.
• W1993543997 cites W2133373613 @default.
• W1993543997 cites W2146223593 @default.
• W1993543997 cites W2150032924 @default.
• W1993543997 cites W2150981663 @default.
• W1993543997 cites W2157634182 @default.
• W1993543997 cites W2159202225 @default.
• W1993543997 cites W2162166182 @default.
• W1993543997 cites W2164036826 @default.
• W1993543997 cites W2165818226 @default.
• W1993543997 cites W2166269098 @default.
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• W1993543997 doi "https://doi.org/10.1371/journal.pcbi.1000878" @default.
• W1993543997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2916859" @default.
• W1993543997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20700496" @default.
• W1993543997 hasPublicationYear "2010" @default.
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