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- W1993547105 endingPage "52" @default.
- W1993547105 startingPage "35" @default.
- W1993547105 abstract "The early developing retinal neuroepithelium is composed of multipotent retinal progenitor cells that differentiate in a time specific manner, giving rise to six major types of neuronal and one type of glial cells. These cells migrate and organize in three distinct nuclear layers divided by two plexiform layers. Apical and adherens junction complexes have a crucial role in this process by the establishment of polarity and adhesion. Changes in these complexes disturb the spatiotemporal aspects of retinogenesis, leading to retinal degeneration resulting in mild or severe impairment of retinal function and vision. In this review, we summarize the mouse models for the different members of the apical and adherens junction protein complexes and describe the main features of their retinal phenotypes. The knowledge acquired from the different mutant animals for these proteins corroborate their importance in retina development and maintenance of normal retinal structure and function. More recently, several studies have tried to unravel the connection between the apical proteins, important cellular signaling pathways and their relation in retina development. Still, the mechanisms by which these proteins function remain largely unknown. Here, we hypothesize how the mammalian apical CRB1 complex might control retinogenesis and prevents onset of Leber congenital amaurosis or retinitis pigmentosa." @default.
- W1993547105 created "2016-06-24" @default.
- W1993547105 creator A5002084311 @default.
- W1993547105 creator A5041535460 @default.
- W1993547105 creator A5056478659 @default.
- W1993547105 date "2014-05-01" @default.
- W1993547105 modified "2023-09-30" @default.
- W1993547105 title "The CRB1 and adherens junction complex proteins in retinal development and maintenance" @default.
- W1993547105 cites W1502837338 @default.
- W1993547105 cites W1522141414 @default.
- W1993547105 cites W1560056935 @default.
- W1993547105 cites W1749297003 @default.
- W1993547105 cites W1873165927 @default.
- W1993547105 cites W1890846155 @default.
- W1993547105 cites W1896219833 @default.
- W1993547105 cites W1963933133 @default.
- W1993547105 cites W1964935836 @default.
- W1993547105 cites W1966032423 @default.
- W1993547105 cites W1966206036 @default.
- W1993547105 cites W1967795278 @default.
- W1993547105 cites W1968954005 @default.
- W1993547105 cites W1971010973 @default.
- W1993547105 cites W1971636570 @default.
- W1993547105 cites W1972769541 @default.
- W1993547105 cites W1974840861 @default.
- W1993547105 cites W1977245174 @default.
- W1993547105 cites W1977284325 @default.
- W1993547105 cites W1977789763 @default.
- W1993547105 cites W1977962361 @default.
- W1993547105 cites W1978625554 @default.
- W1993547105 cites W1979293945 @default.
- W1993547105 cites W1979511698 @default.
- W1993547105 cites W1979535395 @default.
- W1993547105 cites W1979634668 @default.
- W1993547105 cites W1979659851 @default.
- W1993547105 cites W1980670800 @default.
- W1993547105 cites W1981752846 @default.
- W1993547105 cites W1982677883 @default.
- W1993547105 cites W1983776254 @default.
- W1993547105 cites W1984314733 @default.
- W1993547105 cites W1986301677 @default.
- W1993547105 cites W1988829063 @default.
- W1993547105 cites W1989040340 @default.
- W1993547105 cites W1989526275 @default.
- W1993547105 cites W1990188178 @default.
- W1993547105 cites W1992314497 @default.
- W1993547105 cites W1994755074 @default.
- W1993547105 cites W1995140705 @default.
- W1993547105 cites W1997660876 @default.
- W1993547105 cites W1997927831 @default.
- W1993547105 cites W2000345957 @default.
- W1993547105 cites W2000354005 @default.
- W1993547105 cites W2002712265 @default.
- W1993547105 cites W2005066107 @default.
- W1993547105 cites W2005233945 @default.
- W1993547105 cites W2005895705 @default.
- W1993547105 cites W2006249044 @default.
- W1993547105 cites W2006467537 @default.
- W1993547105 cites W2006477079 @default.
- W1993547105 cites W2006559495 @default.
- W1993547105 cites W2007317690 @default.
- W1993547105 cites W2008881930 @default.
- W1993547105 cites W2008927161 @default.
- W1993547105 cites W2009671571 @default.
- W1993547105 cites W2011282245 @default.
- W1993547105 cites W2011634069 @default.
- W1993547105 cites W2012418269 @default.
- W1993547105 cites W2013163435 @default.
- W1993547105 cites W2015062592 @default.
- W1993547105 cites W2015966587 @default.
- W1993547105 cites W2016963135 @default.
- W1993547105 cites W2018142096 @default.
- W1993547105 cites W2023012828 @default.
- W1993547105 cites W2023928365 @default.
- W1993547105 cites W2026302675 @default.
- W1993547105 cites W2026835299 @default.
- W1993547105 cites W2027235566 @default.
- W1993547105 cites W2027513152 @default.
- W1993547105 cites W2029650615 @default.
- W1993547105 cites W2030350058 @default.
- W1993547105 cites W2030609555 @default.
- W1993547105 cites W2031522329 @default.
- W1993547105 cites W2032930150 @default.
- W1993547105 cites W2033798173 @default.
- W1993547105 cites W2034071612 @default.
- W1993547105 cites W2034108449 @default.
- W1993547105 cites W2034191509 @default.
- W1993547105 cites W2034821749 @default.
- W1993547105 cites W2038712067 @default.
- W1993547105 cites W2040531646 @default.
- W1993547105 cites W2041811289 @default.
- W1993547105 cites W2043473335 @default.
- W1993547105 cites W2043982544 @default.
- W1993547105 cites W2045048112 @default.
- W1993547105 cites W2047676549 @default.
- W1993547105 cites W2048501294 @default.
- W1993547105 cites W2048928601 @default.
- W1993547105 cites W2049442129 @default.