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- W1993551761 abstract "ENDOGENOUS expression of opioid receptor-like receptor (ORL1) in human neuroblastoma SK-N-SH cells was demonstrated by binding with nociceptin/ orphanin FQ (N/OFQ). Scatchard analysis of [3H]N/ OFQ saturation binding data gave Kd = 1.3 ± 0.1 nM and Bmax = 158 ± 2.5 fmol/mg protein. N/OFQ stimulation increased [35S]GTPγS binding to cell membranes and attenuated forskolin-induced cAMP accumulation in a concentration-dependent manner. The effects of N/OFQ were eliminated by the pretreatment of pertussis toxin (PTX) but not by the antagonists of opioid receptors, revealing mediation of N/OFQ signal transduction by ORL1 receptor and PTX sensitive G protein(s). The ability of N/OFQ to inhibit cAMP production was greatly reduced after prechallenging with N/OFQ, indicating that ORL1 undergoes homologous desensitization in neuronal cells." @default.
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- W1993551761 date "1997-05-01" @default.
- W1993551761 modified "2023-09-28" @default.
- W1993551761 title "Endogenous opioid receptor-like receptor in human neuroblastoma SK-N-SH cells" @default.
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- W1993551761 doi "https://doi.org/10.1097/00001756-199705260-00024" @default.
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