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• W1993553186 abstract "Polyethylenimine (PEI) shows high transfection efficiency and cytoxicity due to its high amine density. The new disulfide cationic polymer, linear poly(ethylenimine sulfide) (l-PEIS), was synthesized for efficient and safe gene delivery. As the amine density of l-PEIS increased, the transfection efficiency also increased. l-PEIS-6 and l-PEIS-8 show transfection efficiencies that are similar to that of PEI. However, cytotoxicity of l-PEIS was not observed due to the biodegradable disulfide bond. The disulfide bonds are stable in the oxidative extracellular condition and can be degraded rapidly in the reductive intracellular condition. The degradation of l-PEIS in HeLa cells was visualized by fluorescence microscopy using the probe−probe dequenching effect of BODIPY-FL fluorescence dye. l-PEIS was degraded completely within 3 h." @default.
• W1993553186 created "2016-06-24" @default.
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• W1993553186 date "2006-12-23" @default.
• W1993553186 modified "2023-09-24" @default.
• W1993553186 title "Visualization of the Degradation of a Disulfide Polymer, Linear Poly(ethylenimine sulfide), for Gene Delivery" @default.
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• W1993553186 doi "https://doi.org/10.1021/bc060113t" @default.
• W1993553186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17226953" @default.
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