Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993559327> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1993559327 abstract "A number of recent studies have suggested that inhibitors of bacterial DNA gyrase such as nalidixic acid (NAL) and novobiocin possessed genotoxic, DNA-inhibitory and teratogenic properties (Kowalczyk, 1980; McCoy et al., 1980; Czinn et al., 1981; Collins and Johnson, 1979; Lavin, 1981; Mattern and Painter, 1979; Crumplin, 1981; Von Wright and Bridges, 1981). In addition evidence has also been obtained that eukaryotic cells contained DNA gyrase-like enzymes (e.g., topoisomerases II) that are sensitive to inhibition by blockers of DNA gyrase (Baldi et al., 1980; Cozzarelli, 1980; Hsieh and Brutlag, 1980; Liu et al., 1980). Because these findings suggest that inhibitors of putative eukaryotic DNA topoisomerases II might induce genotoxic and developmental effects, it was thought of interest to investigate further the biochemical basis of the effects of NAL, a useful anti-infective agent, on eukaryotic systems. The present study deals with the metabolic effects of NAL on the developing American sea-urchin embryo. It had been shown previously that NAL interfered with sea-urchin development mainly at or following blastulation (Czinn et al., 1981) which was also found to be the stage of embryogenesis susceptible to inhibition by novobiocin and hydroxyurea. Both hydroxyurea and novobiocin inhibit sea-urchin DNA synthesis (Eisenberg et al., 1965; Speck et al., 1982). But while hydroxyurea blocks nucleoside diphosphate reductase, novobiocin is thought to act on a topoisomerase as well as on DNA polymerase (see below). Moreover, while the principal effect of hydroxyurea was blockage of DNA synthesis, which was accompanied by a slight inhibition in RNA synthesis and no effect on protein production; novobiocin-mediated inhibition of DNA synthesis was accompanied by a significant stimulation of protein synthesis (Speck et al., 1982)." @default.
- W1993559327 created "2016-06-24" @default.
- W1993559327 creator A5044255932 @default.
- W1993559327 creator A5062763241 @default.
- W1993559327 creator A5073709590 @default.
- W1993559327 date "1982-10-01" @default.
- W1993559327 modified "2023-09-27" @default.
- W1993559327 title "Possible basis for the dichotomy in the action of DNA gyrase inhibitors on eukaryotes" @default.
- W1993559327 cites W147204557 @default.
- W1993559327 cites W1587622642 @default.
- W1993559327 cites W1980818871 @default.
- W1993559327 cites W1990025001 @default.
- W1993559327 cites W1994808045 @default.
- W1993559327 cites W1999324863 @default.
- W1993559327 cites W2012083162 @default.
- W1993559327 cites W2019415555 @default.
- W1993559327 cites W2022165366 @default.
- W1993559327 cites W2023475491 @default.
- W1993559327 cites W2028628331 @default.
- W1993559327 cites W2042183106 @default.
- W1993559327 cites W2044065128 @default.
- W1993559327 cites W2054735159 @default.
- W1993559327 cites W2057897402 @default.
- W1993559327 cites W2074343173 @default.
- W1993559327 cites W2078767371 @default.
- W1993559327 cites W2081063880 @default.
- W1993559327 cites W2081330288 @default.
- W1993559327 cites W2086176043 @default.
- W1993559327 cites W2088236888 @default.
- W1993559327 cites W2112314064 @default.
- W1993559327 cites W2121547629 @default.
- W1993559327 cites W2147927734 @default.
- W1993559327 cites W4242163156 @default.
- W1993559327 doi "https://doi.org/10.1016/0165-7992(82)90034-3" @default.
- W1993559327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6182461" @default.
- W1993559327 hasPublicationYear "1982" @default.
- W1993559327 type Work @default.
- W1993559327 sameAs 1993559327 @default.
- W1993559327 citedByCount "1" @default.
- W1993559327 crossrefType "journal-article" @default.
- W1993559327 hasAuthorship W1993559327A5044255932 @default.
- W1993559327 hasAuthorship W1993559327A5062763241 @default.
- W1993559327 hasAuthorship W1993559327A5073709590 @default.
- W1993559327 hasConcept C104317684 @default.
- W1993559327 hasConcept C147897179 @default.
- W1993559327 hasConcept C153911025 @default.
- W1993559327 hasConcept C167125095 @default.
- W1993559327 hasConcept C2756471 @default.
- W1993559327 hasConcept C2775876089 @default.
- W1993559327 hasConcept C2778616834 @default.
- W1993559327 hasConcept C2779904463 @default.
- W1993559327 hasConcept C501593827 @default.
- W1993559327 hasConcept C54355233 @default.
- W1993559327 hasConcept C547475151 @default.
- W1993559327 hasConcept C552990157 @default.
- W1993559327 hasConcept C55493867 @default.
- W1993559327 hasConcept C64241487 @default.
- W1993559327 hasConcept C86803240 @default.
- W1993559327 hasConceptScore W1993559327C104317684 @default.
- W1993559327 hasConceptScore W1993559327C147897179 @default.
- W1993559327 hasConceptScore W1993559327C153911025 @default.
- W1993559327 hasConceptScore W1993559327C167125095 @default.
- W1993559327 hasConceptScore W1993559327C2756471 @default.
- W1993559327 hasConceptScore W1993559327C2775876089 @default.
- W1993559327 hasConceptScore W1993559327C2778616834 @default.
- W1993559327 hasConceptScore W1993559327C2779904463 @default.
- W1993559327 hasConceptScore W1993559327C501593827 @default.
- W1993559327 hasConceptScore W1993559327C54355233 @default.
- W1993559327 hasConceptScore W1993559327C547475151 @default.
- W1993559327 hasConceptScore W1993559327C552990157 @default.
- W1993559327 hasConceptScore W1993559327C55493867 @default.
- W1993559327 hasConceptScore W1993559327C64241487 @default.
- W1993559327 hasConceptScore W1993559327C86803240 @default.
- W1993559327 hasLocation W19935593271 @default.
- W1993559327 hasLocation W19935593272 @default.
- W1993559327 hasOpenAccess W1993559327 @default.
- W1993559327 hasPrimaryLocation W19935593271 @default.
- W1993559327 hasRelatedWork W1828691184 @default.
- W1993559327 hasRelatedWork W1983656749 @default.
- W1993559327 hasRelatedWork W2002128513 @default.
- W1993559327 hasRelatedWork W2020288102 @default.
- W1993559327 hasRelatedWork W2020838698 @default.
- W1993559327 hasRelatedWork W2023044969 @default.
- W1993559327 hasRelatedWork W2070600731 @default.
- W1993559327 hasRelatedWork W2084556119 @default.
- W1993559327 hasRelatedWork W2084914085 @default.
- W1993559327 hasRelatedWork W2112463916 @default.
- W1993559327 isParatext "false" @default.
- W1993559327 isRetracted "false" @default.
- W1993559327 magId "1993559327" @default.
- W1993559327 workType "article" @default.