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- W1993560650 abstract "In the past years, several drugs commonly used by allergy specialists have received a black box warning added to their package insert at the direction of the Food and Drug Administration (FDA). A black box warning is the highest level of 5 possible warning categories found in the package insert. The FDA has never articulated the basis for black box warnings. They generally appear to be based on clinical data, but occasionally can be based on serious animal toxicity. In the last several years, several drugs commonly used by allergists have received recommendations for black box warnings. Long-acting beta-agonists (salmeterol and formoterol) received black box warnings because of reports of the occurrences of severe asthma exacerbations in some patients with asthma, with some associated death. Topical calcineurin inhibitors (tacrolimus and pimecrolimus) received a recommendation for application of a black box warnings because of a possible increase of cancer developing in patients taking these drugs. Although the addition of a black box warning was recommended by the FDA Pediatric Advisory Committee for these 2 topical agents, the FDA has not yet implemented this warning. Informed consent principles require that a patient be adequately informed of the risks (among other components) of any recommended treatment. The risks, as described, of the long-acting beta-agonists and topical immunosuppressants should be presented to the patients to aid them in deciding whether they are willing to take these drugs when recommended by their physician." @default.
- W1993560650 created "2016-06-24" @default.
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- W1993560650 date "2006-01-01" @default.
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- W1993560650 title "The “black box” warning and allergy drugs" @default.
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- W1993560650 doi "https://doi.org/10.1016/j.jaci.2005.08.060" @default.
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