FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993563498> ?p ?o ?g. }

• W1993563498 endingPage "78" @default.
• W1993563498 startingPage "69" @default.
• W1993563498 abstract "Mesangial cell proliferation and matrix overproduction characterize many progressive glomerular diseases. Based on currently available data, the role of interleukin-6 (IL-6) in mediating mesangial cell proliferation and matrix production is controversial. The present study attempts to clarify this issue by showing that: (1) IL-6 knock out mice develop a normal glomerular architecture and in particular a normal mesangium. (2) Mesangioproliferative glomerulonephritis induced by Habu snake venom is equally severe in IL-6 knock out mice as in control mice. (3) A continuous seven-day intraperitoneal infusion of 50 micrograms recombinant human IL-6 into rats with a prior minimal (subnephritogenic) injury to mesangial cells does not induce glomerular cell activation, cell proliferation, matrix production, leukocyte influx, platelet influx or proteinuria. (4) A continuous seven-day IL-6 infusion into rats with mesangioproliferative nephritis (anti-Thy 1.1 nephritis) increases matrix protein transcription in the absence of detectable effects on matrix protein accumulation and otherwise has no effect on the natural course of the disease. We conclude from these findings that IL-6 is not an important mediator of mesangial cell proliferation and matrix overproduction in vivo, and that currently little rationale exists to advocate anti-IL-6 therapy in mesangioproliferative disease states." @default.
• W1993563498 created "2016-06-24" @default.
• W1993563498 creator A5001027249 @default.
• W1993563498 creator A5002246212 @default.
• W1993563498 creator A5003900844 @default.
• W1993563498 creator A5020572304 @default.
• W1993563498 creator A5032363556 @default.
• W1993563498 creator A5032897857 @default.
• W1993563498 creator A5059701290 @default.
• W1993563498 creator A5065533886 @default.
• W1993563498 creator A5082087707 @default.
• W1993563498 creator A5090465511 @default.
• W1993563498 date "1997-01-01" @default.
• W1993563498 modified "2023-10-18" @default.
• W1993563498 title "Role of interleukin-6 in mediating mesangial cell proliferation and matrix production in vivo" @default.
• W1993563498 cites W1490094425 @default.
• W1993563498 cites W1537488315 @default.
• W1993563498 cites W1966613111 @default.
• W1993563498 cites W1968005732 @default.
• W1993563498 cites W1974947124 @default.
• W1993563498 cites W1978686331 @default.
• W1993563498 cites W1992294787 @default.
• W1993563498 cites W1993938140 @default.
• W1993563498 cites W1998156838 @default.
• W1993563498 cites W2004894290 @default.
• W1993563498 cites W2013215719 @default.
• W1993563498 cites W2016718666 @default.
• W1993563498 cites W2033465719 @default.
• W1993563498 cites W2040269335 @default.
• W1993563498 cites W2041266681 @default.
• W1993563498 cites W2076892293 @default.
• W1993563498 cites W2078349330 @default.
• W1993563498 cites W2078663145 @default.
• W1993563498 cites W2081550869 @default.
• W1993563498 cites W2082791667 @default.
• W1993563498 cites W2084519792 @default.
• W1993563498 cites W2084768549 @default.
• W1993563498 cites W2085295620 @default.
• W1993563498 cites W2086331541 @default.
• W1993563498 cites W2090283739 @default.
• W1993563498 cites W2097885269 @default.
• W1993563498 cites W2109750471 @default.
• W1993563498 cites W2110153861 @default.
• W1993563498 cites W2116911322 @default.
• W1993563498 cites W2140618470 @default.
• W1993563498 cites W2146559746 @default.
• W1993563498 cites W2149482537 @default.
• W1993563498 cites W2170202796 @default.
• W1993563498 cites W2170346765 @default.
• W1993563498 cites W2171916504 @default.
• W1993563498 cites W2401270048 @default.
• W1993563498 doi "https://doi.org/10.1038/ki.1997.9" @default.
• W1993563498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8995719" @default.
• W1993563498 hasPublicationYear "1997" @default.
• W1993563498 type Work @default.
• W1993563498 sameAs 1993563498 @default.
• W1993563498 citedByCount "53" @default.
• W1993563498 countsByYear W19935634982012 @default.
• W1993563498 countsByYear W19935634982013 @default.
• W1993563498 countsByYear W19935634982014 @default.
• W1993563498 countsByYear W19935634982015 @default.
• W1993563498 countsByYear W19935634982016 @default.
• W1993563498 countsByYear W19935634982017 @default.
• W1993563498 countsByYear W19935634982019 @default.
• W1993563498 countsByYear W19935634982021 @default.
• W1993563498 countsByYear W19935634982022 @default.
• W1993563498 countsByYear W19935634982023 @default.
• W1993563498 crossrefType "journal-article" @default.
• W1993563498 hasAuthorship W1993563498A5001027249 @default.
• W1993563498 hasAuthorship W1993563498A5002246212 @default.
• W1993563498 hasAuthorship W1993563498A5003900844 @default.
• W1993563498 hasAuthorship W1993563498A5020572304 @default.
• W1993563498 hasAuthorship W1993563498A5032363556 @default.
• W1993563498 hasAuthorship W1993563498A5032897857 @default.
• W1993563498 hasAuthorship W1993563498A5059701290 @default.
• W1993563498 hasAuthorship W1993563498A5065533886 @default.
• W1993563498 hasAuthorship W1993563498A5082087707 @default.
• W1993563498 hasAuthorship W1993563498A5090465511 @default.
• W1993563498 hasBestOaLocation W19935634981 @default.
• W1993563498 hasConcept C126322002 @default.
• W1993563498 hasConcept C134018914 @default.
• W1993563498 hasConcept C150903083 @default.
• W1993563498 hasConcept C207001950 @default.
• W1993563498 hasConcept C2777058396 @default.
• W1993563498 hasConcept C2779131090 @default.
• W1993563498 hasConcept C2779937669 @default.
• W1993563498 hasConcept C2780091579 @default.
• W1993563498 hasConcept C2780368995 @default.
• W1993563498 hasConcept C2780688133 @default.
• W1993563498 hasConcept C55493867 @default.
• W1993563498 hasConcept C62112901 @default.
• W1993563498 hasConcept C71924100 @default.
• W1993563498 hasConcept C86803240 @default.
• W1993563498 hasConceptScore W1993563498C126322002 @default.
• W1993563498 hasConceptScore W1993563498C134018914 @default.
• W1993563498 hasConceptScore W1993563498C150903083 @default.
• W1993563498 hasConceptScore W1993563498C207001950 @default.
• W1993563498 hasConceptScore W1993563498C2777058396 @default.

• next