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• W1993567098 abstract "Bone grafts and bone substitutes must be biocompatible osteoconductors with satisfactory mechanical properties similar to native bone. When the bone treatment is conducted under specific conditions, the elasticity module under infra-maximal loading can be optimized to achieve reproducible values. The purpose of this work was to determine the effect of the cleaning and sterilization process using Osteopure on the biomechanical properties of trabecular bone harvested from human femoral heads.Seventy trabecular bone samples were tested: group 1F (fresh samples); group 1N (after application of Osteopure cleaning); group 1S (after Osteopure cleaning and sterilization). Non-destructive and destructive tests (group 1D) were performed. Two fresh femoral heads were used as controls for the destructive test (group 2). The first non-destructive test was applied directly after section (group 1F). Other samples were then purified with Osteopure treatment and a second non-destructive test was conducted (group 1N). A third non-destructive test was conducted after sterilization with 25 kgray radiation (group 1S). Treatments 1 and 2 were performed by OST Developpement SA (Clermont-Ferrand). Finally a destruction test was applied along the directional axis (group 1D). For the 31 samples in group 2 (control) the destructive test was applied along the directional axis immediately after section. Compression tests were performed at a deformation speed of 3 mm/min for 0.3% deformation.The Young module did not exhibit any significant difference between the three steps of the testing in the three orthogonal directions. The Young module was not significantly different between group 1F and group 2 (controls). Maximal force of compression was significantly different (P<0.01). There was a linear relationship between maximal force at rupture and the Young module obtained during destructive tests, for groups 1D and 2 respectively. The compression curves obtained from sterilized samples (group 1D) were not significantly different from those observed for fresh trabecular bone in group 2 (controls).The Young module values measured from 70-673 MPa. For non-destructive tests, the module values were to the order of 64% of those obtained for destructive tests. Decreased maximal force of rupture observed for treated samples in comparison with fresh samples can be explained by the extraction of most of the lipids.The Osteopure method does not alter stiffness of bone allografts. The elasticity module observed in treated bones is close to that observed in fresh bones. Mechanical resistance to compression is however only half the force of compression observed in the hip joint for daily activities. The linear relationship between the elasticity mode and loading required for rupture is not affected by treatment with Osteopure. The advantages related to elimination of prions or viral contamination appear by far to be more important than the minor changes observed in the mechanical characteristics of allografts." @default.
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• W1993567098 date "2004-09-01" @default.
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• W1993567098 title "Propriétés mécaniques de greffons humains provenant de têtes fémorales et traitées par un procédé d’épuration physico-chimique (Ostéopure™)" @default.
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• W1993567098 doi "https://doi.org/10.1016/s0035-1040(04)70171-3" @default.
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