FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993577311> ?p ?o ?g. }

• W1993577311 endingPage "3353" @default.
• W1993577311 startingPage "3345" @default.
• W1993577311 abstract "Transglutaminase-1 (TGase-1) is a Ca²⁺-dependent enzyme capable of cross-linking a variety of proteins and promoting wound healing in the skin. In this study, we examined the role of TGase-1 in proliferation of renal proximal tubular cells (RPTC). TGase-1, but not TGase-2, -5, and -7, was expressed in RPTC. Treatment with monodansylcadarevine (MDC), a selective TGase inhibitor or down-regulation of TGase-1 with small interfering RNA (siRNA) decreased RPTC proliferation. Proliferation of RPTC was accompanied by activation of Akt and Stat-3 (signal transducer and activator of transcription-3). Treatment with MDC or TGase-1 siRNA decreased Stat-3 but not Akt phosphorylation. Further studies showed that the Janus-activated kinase 2 (JAK2) mediates phosphorylation of Stat-3, and knockdown of either JAK2 or Stat-3 by siRNA decreased RPTC proliferation. However, inhibition of TGase-1 decreased phosphorylation of Stat-3 but not JAK2. Overexpression of Stat-3, JAK2, and/or TGase-1 in RPTC revealed that JAK2 is indispensable for TGase-1 to induce Stat-3 phosphorylation and TGase-1 potentiates JAK2-induced Stat-3 phosphorylation. Consistent with these observations, we found that inhibition of TGase-1 and the JAK2-Stat-3 signaling pathway decreased the transcriptional activity of Stat-3 and expression of the Stat-3-targeted genes, cyclin D1 and cyclin E. Conversely, overexpresssion of TGase-1 enhanced the JAK2-dependent transcriptional activity of Stat-3. Finally, TGase-1 was found to interact with JAK2, and this interaction was inhibited by MDC. These results demonstrate that TGase-1 plays an important role in regulation of renal epithelial cell proliferation through the JAK2-Stat-3 signaling pathway." @default.
• W1993577311 created "2016-06-24" @default.
• W1993577311 creator A5029440132 @default.
• W1993577311 creator A5040290579 @default.
• W1993577311 creator A5041867945 @default.
• W1993577311 creator A5048297746 @default.
• W1993577311 creator A5048518436 @default.
• W1993577311 creator A5080412577 @default.
• W1993577311 date "2009-01-01" @default.
• W1993577311 modified "2023-10-12" @default.
• W1993577311 title "Transglutaminase-1 Regulates Renal Epithelial Cell Proliferation through Activation of Stat-3" @default.
• W1993577311 cites W1821858011 @default.
• W1993577311 cites W1966638673 @default.
• W1993577311 cites W1967455040 @default.
• W1993577311 cites W1968240129 @default.
• W1993577311 cites W1969275607 @default.
• W1993577311 cites W1974469880 @default.
• W1993577311 cites W1979410391 @default.
• W1993577311 cites W1986829962 @default.
• W1993577311 cites W1987342012 @default.
• W1993577311 cites W1988376987 @default.
• W1993577311 cites W1993457391 @default.
• W1993577311 cites W1994562522 @default.
• W1993577311 cites W1999147401 @default.
• W1993577311 cites W2002117801 @default.
• W1993577311 cites W2002310871 @default.
• W1993577311 cites W2019525505 @default.
• W1993577311 cites W2032467461 @default.
• W1993577311 cites W2035190080 @default.
• W1993577311 cites W2039339016 @default.
• W1993577311 cites W2042541486 @default.
• W1993577311 cites W2049852463 @default.
• W1993577311 cites W2050378402 @default.
• W1993577311 cites W2056961869 @default.
• W1993577311 cites W2062111689 @default.
• W1993577311 cites W2068994296 @default.
• W1993577311 cites W2072392419 @default.
• W1993577311 cites W2077006158 @default.
• W1993577311 cites W2083294658 @default.
• W1993577311 cites W2084028904 @default.
• W1993577311 cites W2091433642 @default.
• W1993577311 cites W2098437309 @default.
• W1993577311 cites W2098449806 @default.
• W1993577311 cites W2100429833 @default.
• W1993577311 cites W2103618832 @default.
• W1993577311 cites W2106252772 @default.
• W1993577311 cites W2108779312 @default.
• W1993577311 cites W2122456293 @default.
• W1993577311 cites W2126155653 @default.
• W1993577311 cites W2127048642 @default.
• W1993577311 cites W2147339154 @default.
• W1993577311 cites W2149994426 @default.
• W1993577311 cites W2152532651 @default.
• W1993577311 cites W2441829793 @default.
• W1993577311 doi "https://doi.org/10.1074/jbc.m808396200" @default.
• W1993577311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2631946" @default.
• W1993577311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19049964" @default.
• W1993577311 hasPublicationYear "2009" @default.
• W1993577311 type Work @default.
• W1993577311 sameAs 1993577311 @default.
• W1993577311 citedByCount "17" @default.
• W1993577311 countsByYear W19935773112013 @default.
• W1993577311 countsByYear W19935773112014 @default.
• W1993577311 countsByYear W19935773112015 @default.
• W1993577311 countsByYear W19935773112016 @default.
• W1993577311 countsByYear W19935773112017 @default.
• W1993577311 countsByYear W19935773112018 @default.
• W1993577311 countsByYear W19935773112020 @default.
• W1993577311 countsByYear W19935773112023 @default.
• W1993577311 crossrefType "journal-article" @default.
• W1993577311 hasAuthorship W1993577311A5029440132 @default.
• W1993577311 hasAuthorship W1993577311A5040290579 @default.
• W1993577311 hasAuthorship W1993577311A5041867945 @default.
• W1993577311 hasAuthorship W1993577311A5048297746 @default.
• W1993577311 hasAuthorship W1993577311A5048518436 @default.
• W1993577311 hasAuthorship W1993577311A5080412577 @default.
• W1993577311 hasBestOaLocation W19935773111 @default.
• W1993577311 hasConcept C101544691 @default.
• W1993577311 hasConcept C104317684 @default.
• W1993577311 hasConcept C112392421 @default.
• W1993577311 hasConcept C11960822 @default.
• W1993577311 hasConcept C153911025 @default.
• W1993577311 hasConcept C157333092 @default.
• W1993577311 hasConcept C171958077 @default.
• W1993577311 hasConcept C173396325 @default.
• W1993577311 hasConcept C185592680 @default.
• W1993577311 hasConcept C190283241 @default.
• W1993577311 hasConcept C22615655 @default.
• W1993577311 hasConcept C2778277574 @default.
• W1993577311 hasConcept C2778923194 @default.
• W1993577311 hasConcept C2779391668 @default.
• W1993577311 hasConcept C32465701 @default.
• W1993577311 hasConcept C502942594 @default.
• W1993577311 hasConcept C54009773 @default.
• W1993577311 hasConcept C55493867 @default.
• W1993577311 hasConcept C62112901 @default.
• W1993577311 hasConcept C62478195 @default.
• W1993577311 hasConcept C65439459 @default.

• next