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- W1993590336 endingPage "324" @default.
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- W1993590336 abstract "All cells of the body, regardless of the tissue type, contain the same genetic material, but express this genetic material differently. Epigenetics is one process by which differential gene expression within a cell is regulated. Epigenetic mechanisms involve postsynthetic modifications to DNA and/or DNA-associated histones that do not change the DNA sequence itself, but which remodel chromatin, are passed along at each cell division, and occur during and after early development. The CD4+ T cell best represents a cell in which epigenetic mechanisms are used to affect mature cell physiology. As a naïve CD4+ T cell develops into either a Th1 or Th2 cell that secretes predominantly IFN-γ or IL-4, respectively, the expression of one cytokine gene and the permanent silencing of the other is orchestrated using epigenetic mechanisms. Because there appears to be an association between Th1/Th2 cell immunity, behavior, and/or disease, it is possible that an environmentally induced epigenetic change that occurs during Th1/Th2 cell development could explain how certain Th1/Th2-associated conditions develop. This article will review basic epigenetic mechanisms and what is known about how these mechanisms influence cytokine gene expression in a naïve CD4+ T cell as it develops into a Th1 or Th2 cell." @default.
- W1993590336 created "2016-06-24" @default.
- W1993590336 creator A5014930847 @default.
- W1993590336 date "2006-07-01" @default.
- W1993590336 modified "2023-10-17" @default.
- W1993590336 title "Epigenetic regulation of Th1 and Th2 cell development" @default.
- W1993590336 cites W1515586509 @default.
- W1993590336 cites W1519629411 @default.
- W1993590336 cites W1520207918 @default.
- W1993590336 cites W1540263267 @default.
- W1993590336 cites W1544345497 @default.
- W1993590336 cites W1549779921 @default.
- W1993590336 cites W1578776025 @default.
- W1993590336 cites W1609966422 @default.
- W1993590336 cites W1657409241 @default.
- W1993590336 cites W1853022482 @default.
- W1993590336 cites W1861891073 @default.
- W1993590336 cites W1924669997 @default.
- W1993590336 cites W1942668068 @default.
- W1993590336 cites W1945784030 @default.
- W1993590336 cites W1947205448 @default.
- W1993590336 cites W1967064280 @default.
- W1993590336 cites W1967261754 @default.
- W1993590336 cites W1967769642 @default.
- W1993590336 cites W1969138884 @default.
- W1993590336 cites W1972922050 @default.
- W1993590336 cites W1974112332 @default.
- W1993590336 cites W1977655229 @default.
- W1993590336 cites W1979514172 @default.
- W1993590336 cites W1985844966 @default.
- W1993590336 cites W1987560179 @default.
- W1993590336 cites W1988290255 @default.
- W1993590336 cites W1988369300 @default.
- W1993590336 cites W1995070143 @default.
- W1993590336 cites W2001316126 @default.
- W1993590336 cites W2001711719 @default.
- W1993590336 cites W2002883041 @default.
- W1993590336 cites W2004172747 @default.
- W1993590336 cites W2011405307 @default.
- W1993590336 cites W2013050831 @default.
- W1993590336 cites W2016648062 @default.
- W1993590336 cites W2019180113 @default.
- W1993590336 cites W2021919933 @default.
- W1993590336 cites W2027699993 @default.
- W1993590336 cites W2029531273 @default.
- W1993590336 cites W2029903254 @default.
- W1993590336 cites W2030013621 @default.
- W1993590336 cites W2031501484 @default.
- W1993590336 cites W2032456711 @default.
- W1993590336 cites W2035090622 @default.
- W1993590336 cites W2037061225 @default.
- W1993590336 cites W2038271225 @default.
- W1993590336 cites W2040149948 @default.
- W1993590336 cites W2042060537 @default.
- W1993590336 cites W2051304739 @default.
- W1993590336 cites W2051406511 @default.
- W1993590336 cites W2054823635 @default.
- W1993590336 cites W2067004457 @default.
- W1993590336 cites W2067487392 @default.
- W1993590336 cites W2073023385 @default.
- W1993590336 cites W2073157961 @default.
- W1993590336 cites W2074140050 @default.
- W1993590336 cites W2080937611 @default.
- W1993590336 cites W2087526889 @default.
- W1993590336 cites W2090708870 @default.
- W1993590336 cites W2091301099 @default.
- W1993590336 cites W2092263607 @default.
- W1993590336 cites W2093648203 @default.
- W1993590336 cites W2096750803 @default.
- W1993590336 cites W2099042456 @default.
- W1993590336 cites W2100489386 @default.
- W1993590336 cites W2107038650 @default.
- W1993590336 cites W2109881276 @default.
- W1993590336 cites W2115785513 @default.
- W1993590336 cites W2119767265 @default.
- W1993590336 cites W2121417064 @default.
- W1993590336 cites W2122316637 @default.
- W1993590336 cites W2122534935 @default.
- W1993590336 cites W2124116262 @default.
- W1993590336 cites W2130794319 @default.
- W1993590336 cites W2142156537 @default.
- W1993590336 cites W2143658931 @default.
- W1993590336 cites W2144410175 @default.
- W1993590336 cites W2150287216 @default.
- W1993590336 cites W2170548043 @default.
- W1993590336 cites W2171118724 @default.
- W1993590336 cites W2172466148 @default.
- W1993590336 cites W2175077154 @default.
- W1993590336 cites W2177385981 @default.
- W1993590336 cites W2486820350 @default.
- W1993590336 cites W2886978647 @default.
- W1993590336 cites W4212766227 @default.
- W1993590336 cites W4253686169 @default.
- W1993590336 cites W4290960820 @default.
- W1993590336 cites W47940757 @default.
- W1993590336 doi "https://doi.org/10.1016/j.bbi.2005.08.005" @default.
- W1993590336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16226007" @default.
- W1993590336 hasPublicationYear "2006" @default.