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- W1993598329 abstract "Although clinical evidence has suggested that dysregulated fatty acid metabolism is associated with atopic disorders, the molecular basis for such a correlation remains to be demonstrated. In the present study, we analyzed the fatty acid composition in peripheral blood cells of NC/Nga mice, a model for atopic dermatitis (AD). We found that arachidonic acid significantly accumulated in mice with the AD manifestation. In addition, the leucotriene B4-releasing ability upon calcium ionophore A23187 stimulation was potentiated in blood cells. An arachidonic acid accumulation was not apparent in the non-atopic BALB/c strain, but was still observed in healthy NC/Nga mice fed under specific pathogen-free conditions. These results indicate that a disturbed fatty acid metabolism in NC/Nga mice was not a trigger factor for their dermatitis development." @default.
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- W1993598329 date "2001-01-01" @default.
- W1993598329 modified "2023-10-18" @default.
- W1993598329 title "Lack of Effect of the Abnormal Fatty Acid Metabolism in NC/Nga Mice on Their Atopic Dermatitis" @default.
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- W1993598329 doi "https://doi.org/10.1271/bbb.65.431" @default.
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