FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993615180> ?p ?o ?g. }

• W1993615180 endingPage "1179" @default.
• W1993615180 startingPage "1171" @default.
• W1993615180 abstract "Potassium channels play an important role in electrical signaling of excitable cells such as neurons, cardiac myocytes, and vascular smooth muscle cells (VSMCs). In particular, the KCNQ (Kv7) family of voltage-activated K(+) channels functions to stabilize negative resting membrane potentials and thereby opposes electrical excitability. Of the five known members of the mammalian Kv7 family, Kv7.1 was originally recognized for its role in cardiac myocytes, where it contributes to repolarization of the cardiac action potential. Kv7.2 to Kv7.5 were first discovered in neurons, in which they play a well characterized role in neurotransmitter-stimulated action potential firing. Over the past 5 years, important new roles for Kv7 channels have been identified. Kv7 channels have been found to be expressed in VSMCs from several vascular beds where they contribute to the regulation of vascular tone. There is evidence that Kv7.5 channels in VSMCs are targeted by the hormone vasopressin to mediate its physiological vasoconstrictor actions and evidence that neuronal Kv7 channels in the baroreceptors of the aortic arch adjust the sensitivity of the mechanosensitive neurons to changes in arterial blood pressure. These newly identified physiological roles for Kv7 channels in the cardiovascular system warrant increased attention because pharmacological modulators of this family of channels are being used clinically to treat a variety of neurological disorders. This raises questions about the cardiovascular side effects associated with existing therapies, but there is also obvious potential to capitalize on the established and evolving pharmacology of these channels to develop new therapies for cardiovascular diseases." @default.
• W1993615180 created "2016-06-24" @default.
• W1993615180 creator A5067245641 @default.
• W1993615180 creator A5072621540 @default.
• W1993615180 date "2008-08-06" @default.
• W1993615180 modified "2023-09-26" @default.
• W1993615180 title "Cardiovascular KCNQ (Kv7) Potassium Channels: Physiological Regulators and New Targets for Therapeutic Intervention" @default.
• W1993615180 cites W1486616395 @default.
• W1993615180 cites W1488409237 @default.
• W1993615180 cites W1605503794 @default.
• W1993615180 cites W1753089048 @default.
• W1993615180 cites W1892342982 @default.
• W1993615180 cites W1892860009 @default.
• W1993615180 cites W1973027891 @default.
• W1993615180 cites W1985136179 @default.
• W1993615180 cites W1990805641 @default.
• W1993615180 cites W1992759994 @default.
• W1993615180 cites W1994986381 @default.
• W1993615180 cites W1997537641 @default.
• W1993615180 cites W2001460231 @default.
• W1993615180 cites W2002155560 @default.
• W1993615180 cites W2005021150 @default.
• W1993615180 cites W2005291443 @default.
• W1993615180 cites W2015080364 @default.
• W1993615180 cites W2015655346 @default.
• W1993615180 cites W2017032499 @default.
• W1993615180 cites W2018288408 @default.
• W1993615180 cites W2019787059 @default.
• W1993615180 cites W2019959711 @default.
• W1993615180 cites W2020794407 @default.
• W1993615180 cites W2024733121 @default.
• W1993615180 cites W2031749158 @default.
• W1993615180 cites W2038328684 @default.
• W1993615180 cites W2039033026 @default.
• W1993615180 cites W2040081725 @default.
• W1993615180 cites W2044689290 @default.
• W1993615180 cites W2045747096 @default.
• W1993615180 cites W2046799089 @default.
• W1993615180 cites W2047069083 @default.
• W1993615180 cites W2048671449 @default.
• W1993615180 cites W2051979908 @default.
• W1993615180 cites W2052235765 @default.
• W1993615180 cites W2052509491 @default.
• W1993615180 cites W2055681900 @default.
• W1993615180 cites W2058346833 @default.
• W1993615180 cites W2059690890 @default.
• W1993615180 cites W2060270607 @default.
• W1993615180 cites W2060974177 @default.
• W1993615180 cites W2061062706 @default.
• W1993615180 cites W2062957466 @default.
• W1993615180 cites W2065174881 @default.
• W1993615180 cites W2066008360 @default.
• W1993615180 cites W2070261767 @default.
• W1993615180 cites W2071644822 @default.
• W1993615180 cites W2079373480 @default.
• W1993615180 cites W2079505353 @default.
• W1993615180 cites W2081587319 @default.
• W1993615180 cites W2081772709 @default.
• W1993615180 cites W2083579220 @default.
• W1993615180 cites W2083945384 @default.
• W1993615180 cites W2103752980 @default.
• W1993615180 cites W2114685731 @default.
• W1993615180 cites W2128953287 @default.
• W1993615180 cites W2129132447 @default.
• W1993615180 cites W2131128903 @default.
• W1993615180 cites W2137461462 @default.
• W1993615180 cites W2142318256 @default.
• W1993615180 cites W2144590281 @default.
• W1993615180 cites W2146215035 @default.
• W1993615180 cites W2148583712 @default.
• W1993615180 cites W2149307089 @default.
• W1993615180 cites W2152729849 @default.
• W1993615180 cites W2154588303 @default.
• W1993615180 cites W2158713173 @default.
• W1993615180 cites W2159579442 @default.
• W1993615180 cites W2159911721 @default.
• W1993615180 cites W2163975371 @default.
• W1993615180 cites W2166683822 @default.
• W1993615180 cites W2168858520 @default.
• W1993615180 cites W2169119723 @default.
• W1993615180 cites W2171101150 @default.
• W1993615180 cites W2318722586 @default.
• W1993615180 cites W2411134719 @default.
• W1993615180 cites W61928364 @default.
• W1993615180 cites W74452585 @default.
• W1993615180 doi "https://doi.org/10.1124/mol.108.049825" @default.
• W1993615180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18684841" @default.
• W1993615180 hasPublicationYear "2008" @default.
• W1993615180 type Work @default.
• W1993615180 sameAs 1993615180 @default.
• W1993615180 citedByCount "96" @default.
• W1993615180 countsByYear W19936151802012 @default.
• W1993615180 countsByYear W19936151802013 @default.
• W1993615180 countsByYear W19936151802014 @default.
• W1993615180 countsByYear W19936151802015 @default.
• W1993615180 countsByYear W19936151802016 @default.
• W1993615180 countsByYear W19936151802017 @default.
• W1993615180 countsByYear W19936151802018 @default.

• next