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- W1993617154 abstract "Modern means of communication rely on electric fields and currents to carry the flow of information. In contrast, biological systems follow a different paradigm that uses ion gradients and currents, flows of small molecules, and membrane electric potentials. Living organisms use a sophisticated arsenal of membrane receptors, channels, and pumps to control signal transduction to a degree that is unmatched by manmade devices. Electronic circuits that use such biological components could achieve drastically increased functionality; however, this approach requires nearly seamless integration of biological and manmade structures. We present a versatile hybrid platform for such integration that uses shielded nanowires (NWs) that are coated with a continuous lipid bilayer. We show that when shielded silicon NW transistors incorporate transmembrane peptide pores gramicidin A and alamethicin in the lipid bilayer they can achieve ionic to electronic signal transduction by using voltage-gated or chemically gated ion transport through the membrane pores." @default.
- W1993617154 created "2016-06-24" @default.
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- W1993617154 date "2009-08-18" @default.
- W1993617154 modified "2023-10-18" @default.
- W1993617154 title "Bioelectronic silicon nanowire devices using functional membrane proteins" @default.
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- W1993617154 doi "https://doi.org/10.1073/pnas.0904850106" @default.
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