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• W1993635085 abstract "p63, a transcription factor and p53 family protein, plays a crucial role in tumor suppression and development of various epithelial tissues. While p63 expression is controlled mostly by post-translational modifications, recent studies indicate that transcriptional and posttranscriptional regulations are essential for proper p63 expression. Here, we investigated the regulation of p63 expression by poly (C)-binding protein 1 (PCBP1, also known as hnRNP-E1 and αCP1). We found that knockdown of PCBP1 decreases the level of p63 transcript and protein. We also found that PCBP1 regulates the stability of p63 mRNA via binding to p63 3'UTR. Additionally, we found that a CU-rich element (CUE) in p63 3'UTR is bound by and responsive to PCBP1. Together, we conclude that PCBP1 regulates p63 expression via mRNA stability." @default.
• W1993635085 created "2016-06-24" @default.
• W1993635085 creator A5002191937 @default.
• W1993635085 creator A5059462159 @default.
• W1993635085 creator A5091422402 @default.
• W1993635085 date "2013-08-07" @default.
• W1993635085 modified "2023-10-07" @default.
• W1993635085 title "Poly (C)-Binding Protein 1 Regulates p63 Expression through mRNA Stability" @default.
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• W1993635085 doi "https://doi.org/10.1371/journal.pone.0071724" @default.
• W1993635085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3737132" @default.
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• W1993635085 hasPublicationYear "2013" @default.
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