Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993640941> ?p ?o ?g. }
- W1993640941 endingPage "167" @default.
- W1993640941 startingPage "152" @default.
- W1993640941 abstract "The blood-brain barrier (BBB) is constituted by a specialized vascular endothelium that interacts directly with astrocytes, neurons and pericytes. It protects the brain from the molecules of the systemic circulation but it has to be overcome for the proper treatment of brain cancer, psychiatric disorders or neurodegenerative diseases, which are dramatically increasing as the population ages. In the present work we have revised the current knowledge on the cellular structure of the BBB and the different procedures utilized currently and those proposed to cross it. Chemical modifications of the drugs, such as increasing their lipophilicity, turn them more prone to be internalized in the brain. Other mechanisms are the use of molecular tools to bind the drugs such as small immunoglobulins, liposomes or nanoparticles that will act as Trojan Horses favoring the drug delivery in brain. This fusion of the classical pharmacology with nanotechnology has opened a wide field to many different approaches with promising results to hypothesize that BBB will not be a major problem for the new generation of neuroactive drugs. The present review provides an overview of all state-of-the-art of the BBB structure and function, as well as of the classic strategies and these appeared in recent years to deliver drugs into the brain for the treatment of Central Nervous System (CNS) diseases." @default.
- W1993640941 created "2016-06-24" @default.
- W1993640941 creator A5011710369 @default.
- W1993640941 creator A5014756635 @default.
- W1993640941 creator A5015696597 @default.
- W1993640941 creator A5020881196 @default.
- W1993640941 creator A5051664900 @default.
- W1993640941 creator A5051899114 @default.
- W1993640941 creator A5053941641 @default.
- W1993640941 creator A5075686017 @default.
- W1993640941 creator A5079640025 @default.
- W1993640941 creator A5086116664 @default.
- W1993640941 date "2014-07-21" @default.
- W1993640941 modified "2023-10-05" @default.
- W1993640941 title "The blood-brain barrier: Structure, function and therapeutic approaches to cross it" @default.
- W1993640941 cites W1491991731 @default.
- W1993640941 cites W1564553363 @default.
- W1993640941 cites W158557124 @default.
- W1993640941 cites W1585640564 @default.
- W1993640941 cites W1607895415 @default.
- W1993640941 cites W1655997880 @default.
- W1993640941 cites W1796054280 @default.
- W1993640941 cites W1931818816 @default.
- W1993640941 cites W1958172963 @default.
- W1993640941 cites W1965838612 @default.
- W1993640941 cites W1965950604 @default.
- W1993640941 cites W1966187612 @default.
- W1993640941 cites W1966782114 @default.
- W1993640941 cites W1966904260 @default.
- W1993640941 cites W1967908989 @default.
- W1993640941 cites W1968214306 @default.
- W1993640941 cites W1969547131 @default.
- W1993640941 cites W1969729759 @default.
- W1993640941 cites W1973304468 @default.
- W1993640941 cites W1974315180 @default.
- W1993640941 cites W1975140802 @default.
- W1993640941 cites W1976375376 @default.
- W1993640941 cites W1979524509 @default.
- W1993640941 cites W1981177136 @default.
- W1993640941 cites W1982531351 @default.
- W1993640941 cites W1983533408 @default.
- W1993640941 cites W1983582201 @default.
- W1993640941 cites W1984998073 @default.
- W1993640941 cites W1985495900 @default.
- W1993640941 cites W1985811126 @default.
- W1993640941 cites W1985944040 @default.
- W1993640941 cites W1987820290 @default.
- W1993640941 cites W1989896581 @default.
- W1993640941 cites W1992907077 @default.
- W1993640941 cites W1994125288 @default.
- W1993640941 cites W1994812037 @default.
- W1993640941 cites W1995565380 @default.
- W1993640941 cites W1998038531 @default.
- W1993640941 cites W1998548897 @default.
- W1993640941 cites W1999837778 @default.
- W1993640941 cites W2003116578 @default.
- W1993640941 cites W2005447528 @default.
- W1993640941 cites W2006840751 @default.
- W1993640941 cites W2009244092 @default.
- W1993640941 cites W2010418410 @default.
- W1993640941 cites W2011942915 @default.
- W1993640941 cites W2013458878 @default.
- W1993640941 cites W2014485768 @default.
- W1993640941 cites W2015504271 @default.
- W1993640941 cites W2015541518 @default.
- W1993640941 cites W2018121350 @default.
- W1993640941 cites W2018473726 @default.
- W1993640941 cites W2021759214 @default.
- W1993640941 cites W2022047142 @default.
- W1993640941 cites W2022443359 @default.
- W1993640941 cites W2025035152 @default.
- W1993640941 cites W2025724408 @default.
- W1993640941 cites W2026755460 @default.
- W1993640941 cites W2028069243 @default.
- W1993640941 cites W2028441136 @default.
- W1993640941 cites W2030282028 @default.
- W1993640941 cites W2032432537 @default.
- W1993640941 cites W2035703861 @default.
- W1993640941 cites W2037877043 @default.
- W1993640941 cites W2038989792 @default.
- W1993640941 cites W2040084528 @default.
- W1993640941 cites W2041140779 @default.
- W1993640941 cites W2041703524 @default.
- W1993640941 cites W2041919596 @default.
- W1993640941 cites W2042239732 @default.
- W1993640941 cites W2044872202 @default.
- W1993640941 cites W2046826638 @default.
- W1993640941 cites W2050589760 @default.
- W1993640941 cites W2055137108 @default.
- W1993640941 cites W2056318837 @default.
- W1993640941 cites W2059258493 @default.
- W1993640941 cites W2060187394 @default.
- W1993640941 cites W2060231435 @default.
- W1993640941 cites W2061389108 @default.
- W1993640941 cites W2062970451 @default.
- W1993640941 cites W2065318944 @default.
- W1993640941 cites W2065566358 @default.
- W1993640941 cites W2067733328 @default.