FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993645278> ?p ?o ?g. }

• W1993645278 endingPage "13904" @default.
• W1993645278 startingPage "13891" @default.
• W1993645278 abstract "In atherogenesis, macrophage-derived apolipoprotein E (apoE) has an athero-protective role by a mechanism that is not fully understood. We investigated the regulatory mechanisms involved in the modulation of apoE expression in macrophages. The experiments showed that the promoters of all genes of the apoE/apoCI/apoCIV/apoCII gene cluster are enhanced by multienhancer 2 (ME.2), a regulatory region that is located 15.9 kb downstream of the apoE gene. ME.2 interacts with the apoE promoter in a macrophage-specific manner. Transient transfections in RAW 264.7 macrophages showed that the activity of ME.2 was strongly decreased by deletion of either 87 bp from the 5' end or 131 bp from the 3' end. We determined that the minimal fragment of this promoter that can be activated by ME.2 is the proximal -100/+73 region. The analysis of the deletion mutants of ME.2 revealed the importance of the 5' end of ME.2 in apoE promoter transactivation. Chromatin conformational capture assays demonstrated that both ME.2 and ME.1 physically interacted with the apoE promoter in macrophages. Our data showed that phorbol 12-myristate 13-acetate-induced differentiation of macrophages is accompanied by a robust induction of apoE and STAT1 expression. In macrophages (but not in hepatocytes), STAT1 up-regulated apoE gene expression via ME.2. The STAT1 binding site was located in the 174-182 region of ME.2. In conclusion, the specificity of the interactions between the two multienhancers (ME.1 and ME.2) and the apoE promoter indicates that these distal regulatory elements play an important role in the modulation of apoE gene expression in a cell-specific manner." @default.
• W1993645278 created "2016-06-24" @default.
• W1993645278 creator A5015001336 @default.
• W1993645278 creator A5028981837 @default.
• W1993645278 creator A5039379327 @default.
• W1993645278 creator A5045427467 @default.
• W1993645278 creator A5058779133 @default.
• W1993645278 creator A5073391419 @default.
• W1993645278 date "2011-04-01" @default.
• W1993645278 modified "2023-10-18" @default.
• W1993645278 title "Macrophage-specific Up-regulation of Apolipoprotein E Gene Expression by STAT1 Is Achieved via Long Range Genomic Interactions" @default.
• W1993645278 cites W1489708200 @default.
• W1993645278 cites W1530975353 @default.
• W1993645278 cites W1552597422 @default.
• W1993645278 cites W1554323039 @default.
• W1993645278 cites W1590095886 @default.
• W1993645278 cites W1595513249 @default.
• W1993645278 cites W1859624620 @default.
• W1993645278 cites W1874149516 @default.
• W1993645278 cites W1964814612 @default.
• W1993645278 cites W1965828942 @default.
• W1993645278 cites W1968415554 @default.
• W1993645278 cites W1973924691 @default.
• W1993645278 cites W1975379193 @default.
• W1993645278 cites W1983430442 @default.
• W1993645278 cites W1986621775 @default.
• W1993645278 cites W1987299322 @default.
• W1993645278 cites W1988205526 @default.
• W1993645278 cites W1992980650 @default.
• W1993645278 cites W1997476907 @default.
• W1993645278 cites W2003798182 @default.
• W1993645278 cites W2004818175 @default.
• W1993645278 cites W2008099488 @default.
• W1993645278 cites W2017319919 @default.
• W1993645278 cites W2017640755 @default.
• W1993645278 cites W2023647145 @default.
• W1993645278 cites W2028841673 @default.
• W1993645278 cites W2030442022 @default.
• W1993645278 cites W2035252462 @default.
• W1993645278 cites W2042142779 @default.
• W1993645278 cites W2048890665 @default.
• W1993645278 cites W2051024633 @default.
• W1993645278 cites W2054099490 @default.
• W1993645278 cites W2062978314 @default.
• W1993645278 cites W2064879068 @default.
• W1993645278 cites W2065152225 @default.
• W1993645278 cites W2077219082 @default.
• W1993645278 cites W2080690412 @default.
• W1993645278 cites W2085574825 @default.
• W1993645278 cites W2086495464 @default.
• W1993645278 cites W2087533793 @default.
• W1993645278 cites W2087757733 @default.
• W1993645278 cites W2092834104 @default.
• W1993645278 cites W2093392246 @default.
• W1993645278 cites W2098975624 @default.
• W1993645278 cites W2110606487 @default.
• W1993645278 cites W2120266983 @default.
• W1993645278 cites W2127791131 @default.
• W1993645278 cites W2134010411 @default.
• W1993645278 cites W2144076105 @default.
• W1993645278 cites W2145854562 @default.
• W1993645278 cites W2156178535 @default.
• W1993645278 cites W2162330918 @default.
• W1993645278 cites W2165774651 @default.
• W1993645278 cites W2169149496 @default.
• W1993645278 cites W2169359444 @default.
• W1993645278 cites W2323892235 @default.
• W1993645278 cites W2328284874 @default.
• W1993645278 doi "https://doi.org/10.1074/jbc.m110.179572" @default.
• W1993645278 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3077590" @default.
• W1993645278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21372127" @default.
• W1993645278 hasPublicationYear "2011" @default.
• W1993645278 type Work @default.
• W1993645278 sameAs 1993645278 @default.
• W1993645278 citedByCount "24" @default.
• W1993645278 countsByYear W19936452782012 @default.
• W1993645278 countsByYear W19936452782013 @default.
• W1993645278 countsByYear W19936452782014 @default.
• W1993645278 countsByYear W19936452782015 @default.
• W1993645278 countsByYear W19936452782016 @default.
• W1993645278 countsByYear W19936452782017 @default.
• W1993645278 countsByYear W19936452782018 @default.
• W1993645278 countsByYear W19936452782019 @default.
• W1993645278 countsByYear W19936452782020 @default.
• W1993645278 countsByYear W19936452782021 @default.
• W1993645278 countsByYear W19936452782022 @default.
• W1993645278 crossrefType "journal-article" @default.
• W1993645278 hasAuthorship W1993645278A5015001336 @default.
• W1993645278 hasAuthorship W1993645278A5028981837 @default.
• W1993645278 hasAuthorship W1993645278A5039379327 @default.
• W1993645278 hasAuthorship W1993645278A5045427467 @default.
• W1993645278 hasAuthorship W1993645278A5058779133 @default.
• W1993645278 hasAuthorship W1993645278A5073391419 @default.
• W1993645278 hasBestOaLocation W19936452781 @default.
• W1993645278 hasConcept C101762097 @default.
• W1993645278 hasConcept C104317684 @default.
• W1993645278 hasConcept C1292079 @default.
• W1993645278 hasConcept C134320426 @default.

• next