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- W1993646750 abstract "Zinc through a zinc binding site is known to modulate the binding of agonists at the NMDA receptor. In the present study, the ability of zinc oxide to alter the specific binding of [3H]CGP-39653, a competitive NMDA receptor antagonist, was determined in homogenate of rat brain tissue. Analysis of saturation experiments indicated that zinc oxide significantly increased the Kd without changing Bmax of [3H]CGP-39653 binding. Furthermore, the effect of ZnO on glutamate and glycine displacement of [3H]CGP-39653 binding was determined. The results of the [3H]CGP-39653 displacement study indicated that ZnO decreases the glutamate and glycine displacement of [3H]CGP-39653 binding." @default.
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- W1993646750 date "1997-01-01" @default.
- W1993646750 modified "2023-09-27" @default.
- W1993646750 title "Modulation of a competitive N-methyl-d-aspartate receptor antagonist binding by zinc oxide" @default.
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- W1993646750 doi "https://doi.org/10.1016/s0006-8993(96)01204-8" @default.
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