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W1993658423 abstract "Novel 2,4-diaminopyrimidine-based small molecule renin inhibitors are disclosed. Through high throughput screening, parallel synthesis, X-ray crystallography, and structure based drug design, we have developed the first non-chiral, non-peptidic, small molecular template to possess moderate potency against renin. The designed compounds consist of a novel 6-ethyl-5-(1,2,3,4-tetrahydroquinolin-7-yl)pyrimidine-2,4-diamine ring system that exhibit moderate potency (IC50: 91–650 nM) against renin while remaining ‘Rule-of-five’ compliant." @default.
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W1993658423 date "2007-07-01" @default.
W1993658423 modified "2023-10-03" @default.
W1993658423 title "Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors" @default.
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W1993658423 doi "https://doi.org/10.1016/j.bmcl.2007.04.052" @default.
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