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- W1993663299 abstract "Immunization strategy with plasmid DNA has great potential to modulate humoral and cellular immune responses that protect against cancer as well as infectious diseases. The particle-mediated gene transfer system (gene gun) is capable of delivering cytokine genes into the in vivo microenvironment of a living animal without any type of viral vector [ [1] Yang N.S. Sun W.H. Gene gun and other non-viral approaches for cancer gene therapy. Nat Med. 1995; 1: 481-483 Crossref PubMed Scopus (166) Google Scholar ]. Gene gun-mediated in vivo transfer of cytokine genes has recently resulted in the regression of tumors in rodent animal models [ 1 Yang N.S. Sun W.H. Gene gun and other non-viral approaches for cancer gene therapy. Nat Med. 1995; 1: 481-483 Crossref PubMed Scopus (166) Google Scholar , 2 Wang J. Murakami T. Hakamata Y. Ajiki T. Jinbu Y. Akasaka Y. et al. Gene gun-mediated oral mucosal transfer of interleukin 12 cDNA coupled with an irradiated melanoma vaccine in a hamster model: successful treatment of oral melanoma and distant skin lesion. Cancer Gene Ther. 2001; 8: 705-712 Crossref PubMed Scopus (35) Google Scholar , 3 Ajiki T. Murakami T. Kobayashi Y. Hakamata Y. Wang J. Inoue S. et al. Long-lasting gene expression by particle-mediated intramuscular transfection modified with bupivacaine: combinatorial gene therapy with IL-12 and IL-18 cDNA against rat sarcoma at a distant site. Cancer Gene Ther. 2003; 10: 318-329 Crossref PubMed Scopus (21) Google Scholar ]. This technique also allows multiple genes to deliver to the target tissue, and is most suitable for assessing the combination therapy of cytokine genes." @default.
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- W1993663299 title "Synergistic anti-tumor effect by combinatorial gene-gun therapy using IL-23 and IL-18 cDNA" @default.
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- W1993663299 doi "https://doi.org/10.1016/j.jdermsci.2004.08.001" @default.
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