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- W1993667066 abstract "Conditioned media from cultures of human metastatic Hs294T melanoma cells contain a factor/factors that promote(s) fibro-blast-mediated contraction of collagen lattices, and stimulate(s) fibroblast glycosaminoglycan (GAG) synthesis. Complete medium from melanoma cell cultures stimulated fibroblast hyaluronate synthesis 9.3-fold, and sulphated GAG synthesis 2.6-fold, as measured by 3H-glucosamine incorporation. 35SO4 incorporation into sulphated GAGS was essentially unaltered, the net result being a decrease in the degree of sulphation. Fibroblasts synthesized hyaluronate with an increased molecular weight when grown in the presence of the melanoma-cell culture medium, while the molecular weights of heparan and chondroitin sulphates remained essentially unaltered. Our results indicate that the tumour-cell-derived factor(s) stimulate(s) changes in fibroblast glycosaminoglycan synthesis, and that these changes may facilitate tumour cell invasion in vivo. © 1992 Wiley-Liss, Inc." @default.
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- W1993667066 date "1992-09-30" @default.
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- W1993667066 title "Human melanoma cell-derived factor(S) stimulate fibroblast glycosaminoglycan synthesis" @default.
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- W1993667066 doi "https://doi.org/10.1002/ijc.2910520327" @default.
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