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- W1993669198 abstract "High affinity uptake of choline, GABA, norepinephrine and serotonin into synaptosomes and ganglioside content of cortices served as indices of synaptic development. Both parameters indicated that phenylacetate contributed to the retarded maturation of synapses in the cerebrum of the adult rat, previously treated with either phenylacetate or one of its precursors, phenylalanine (with p-CPA) and phenylethylamine, during the first 21 days of life. In these groups of rats, which also exhibited a pronounced deficit in learning capacity, the velocity of high affinity synaptosomal uptake of choline was reduced to a greater extent than that of GABA, and there was a profound decrease in the ganglioside content of cerebral cortex. In contrast, synaptic maturation and behavior of control and phenylpyruvate treated animals were similar. These findings lend strong support to our contention that phenylacetate, produced in excessive amounts in PKU, is most likely a primary cause of the mental retardation." @default.
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- W1993669198 date "1980-10-01" @default.
- W1993669198 modified "2023-09-25" @default.
- W1993669198 title "Phenylacetate and brain dysfunction in experimental phenylketonuria: Synaptic development" @default.
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- W1993669198 doi "https://doi.org/10.1016/0024-3205(80)90221-0" @default.
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