FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993669214> ?p ?o ?g. }

• W1993669214 abstract "Anti-pseudomonas aminoglycosides, such as amikacin and tobramycin, are used in the treatment of Pseudomonas aeruginosa infections. However, their use is linked to the development of resistance. During the last decade, the MexXY multidrug efflux system has been comprehensively studied, and numerous reports of laboratory and clinical isolates have been published. This system has been increasingly recognized as one of the primary determinants of aminoglycoside resistance in P. aeruginosa. In P. aeruginosa cystic fibrosis isolates, upregulation of the pump is considered the most common mechanism of aminoglycoside resistance. Non-fermentative Gram-negative pathogens possessing very close MexXY orthologs such as Achromobacter xylosoxidans and various Burkholderia species (e.g., Burkholderia pseudomallei and B. cepacia complexes), but not B. gladioli, are intrinsically resistant to aminoglycosides. Here, we summarize the properties (e.g., discovery, mechanism, gene expression, clinical significance) of the P. aeruginosa MexXY pump and other aminoglycoside efflux pumps such as AcrD of Escherichia coli, AmrAB-OprA of B. pseudomallei, and AdeABC of Acinetobacter baumannii. MexXY inducibility of the PA5471 gene product, which is dependent on ribosome inhibition or oxidative stress, is noteworthy. Moreover, the discovery of the cognate outer membrane component (OprA) of MexXY in the multidrug-resistant clinical isolate PA7, serotype O12 deserves special attention." @default.
• W1993669214 created "2016-06-24" @default.
• W1993669214 creator A5000086594 @default.
• W1993669214 creator A5036904973 @default.
• W1993669214 creator A5054911802 @default.
• W1993669214 date "2012-01-01" @default.
• W1993669214 modified "2023-10-14" @default.
• W1993669214 title "MexXY multidrug efflux system of Pseudomonas aeruginosa" @default.
• W1993669214 cites W1523903390 @default.
• W1993669214 cites W1573080626 @default.
• W1993669214 cites W1582758854 @default.
• W1993669214 cites W1598199862 @default.
• W1993669214 cites W1665675542 @default.
• W1993669214 cites W1687650400 @default.
• W1993669214 cites W1760995301 @default.
• W1993669214 cites W1785018154 @default.
• W1993669214 cites W1816601709 @default.
• W1993669214 cites W1879460511 @default.
• W1993669214 cites W1895934393 @default.
• W1993669214 cites W1897808528 @default.
• W1993669214 cites W1920534944 @default.
• W1993669214 cites W1939293279 @default.
• W1993669214 cites W1968759341 @default.
• W1993669214 cites W1970517964 @default.
• W1993669214 cites W1970798262 @default.
• W1993669214 cites W1970927928 @default.
• W1993669214 cites W1972381405 @default.
• W1993669214 cites W1974095433 @default.
• W1993669214 cites W1975361143 @default.
• W1993669214 cites W1977593863 @default.
• W1993669214 cites W1979152503 @default.
• W1993669214 cites W1981366496 @default.
• W1993669214 cites W1982118335 @default.
• W1993669214 cites W1984876660 @default.
• W1993669214 cites W1984899973 @default.
• W1993669214 cites W1985735103 @default.
• W1993669214 cites W1991540813 @default.
• W1993669214 cites W1992857363 @default.
• W1993669214 cites W1993697405 @default.
• W1993669214 cites W1994780701 @default.
• W1993669214 cites W1999194567 @default.
• W1993669214 cites W2000470168 @default.
• W1993669214 cites W2001775561 @default.
• W1993669214 cites W2001912852 @default.
• W1993669214 cites W2007889243 @default.
• W1993669214 cites W2016075837 @default.
• W1993669214 cites W2017608260 @default.
• W1993669214 cites W2020077218 @default.
• W1993669214 cites W2024905726 @default.
• W1993669214 cites W2026038421 @default.
• W1993669214 cites W2026895376 @default.
• W1993669214 cites W2029792653 @default.
• W1993669214 cites W2030047338 @default.
• W1993669214 cites W2031738351 @default.
• W1993669214 cites W2033794725 @default.
• W1993669214 cites W2034588929 @default.
• W1993669214 cites W2035268922 @default.
• W1993669214 cites W2037248614 @default.
• W1993669214 cites W2040853326 @default.
• W1993669214 cites W2043698490 @default.
• W1993669214 cites W2045575387 @default.
• W1993669214 cites W2051230785 @default.
• W1993669214 cites W2052386209 @default.
• W1993669214 cites W2054315244 @default.
• W1993669214 cites W2054557328 @default.
• W1993669214 cites W2057418340 @default.
• W1993669214 cites W2057481588 @default.
• W1993669214 cites W2062115406 @default.
• W1993669214 cites W2064163165 @default.
• W1993669214 cites W2064442807 @default.
• W1993669214 cites W2065827250 @default.
• W1993669214 cites W2066024448 @default.
• W1993669214 cites W2070123919 @default.
• W1993669214 cites W2070196678 @default.
• W1993669214 cites W2071083537 @default.
• W1993669214 cites W2073804693 @default.
• W1993669214 cites W2074619179 @default.
• W1993669214 cites W2075287054 @default.
• W1993669214 cites W2076233570 @default.
• W1993669214 cites W2077083161 @default.
• W1993669214 cites W2078785671 @default.
• W1993669214 cites W2082367839 @default.
• W1993669214 cites W2087589133 @default.
• W1993669214 cites W2088695057 @default.
• W1993669214 cites W2091659282 @default.
• W1993669214 cites W2096172849 @default.
• W1993669214 cites W2097853356 @default.
• W1993669214 cites W2098598894 @default.
• W1993669214 cites W2100579826 @default.
• W1993669214 cites W2101808312 @default.
• W1993669214 cites W2103131258 @default.
• W1993669214 cites W2104818315 @default.
• W1993669214 cites W2105226320 @default.
• W1993669214 cites W2106359046 @default.
• W1993669214 cites W2107250776 @default.
• W1993669214 cites W2107403034 @default.
• W1993669214 cites W2109086196 @default.
• W1993669214 cites W2109611387 @default.
• W1993669214 cites W2111839343 @default.
• W1993669214 cites W2111903898 @default.

• next