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• W1993669821 abstract "We present a method for high-throughput cytological profiling by microscopy. Our system provides quantitative multidimensional measures of individual cell states over wide ranges of perturbations. We profile dose-dependent phenotypic effects of drugs in human cell culture with a titration-invariant similarity score (TISS). This method successfully categorized blinded drugs and suggested targets for drugs of uncertain mechanism. Multivariate single-cell analysis is a starting point for identifying relationships among drug effects at a systems level and a step toward phenotypic profiling at the single-cell level. Our methods will be useful for discovering the mechanism and predicting the toxicity of new drugs." @default.
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• W1993669821 date "2004-11-12" @default.
• W1993669821 modified "2023-10-16" @default.
• W1993669821 title "Multidimensional Drug Profiling By Automated Microscopy" @default.
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• W1993669821 doi "https://doi.org/10.1126/science.1100709" @default.
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