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- W1993670218 abstract "Objectives To record the number of children with withdrawal symptoms after the administration of sedatives for mechanical ventilation, and to discuss the possible connection with the administration of midazolam. Design Retrospective data collection from case records and charts. Setting Medical and surgical intensive care unit (ICU) in a university hospital. Patients Children 6 months to 14 yrs of age who required sedation for mechanical ventilation (n = 40). Interventions None. Measurements and Main Results Kind and amount of sedatives and analgesics, duration of administration, and occurrence of withdrawal symptoms. The frequency of withdrawal symptoms was 35% (14/40) of the sedated children. A total dose of midazolam of >60 mg/kg was strongly significantly associated with occurrence of withdrawal. Statistical analysis to determine the occurrence of withdrawal associated with the administration of morphine was not possible. Conclusions Signs and symptoms of a withdrawal reaction were observed in several children. The occurrence of withdrawal was statistically related to high doses of midazolam, but it was not possible to determine the influence of morphine. If large doses of midazolam and opioids have been administered, there may be justification for reducing the dose gradually instead of abruptly, or using longer-acting benzodiazepines or opiods on discontinuation of sedation. (Crit Care Med 1999; 27:196-199)" @default.
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- W1993670218 date "1999-01-01" @default.
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- W1993670218 title "Occurrence of withdrawal in critically ill sedated children" @default.
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- W1993670218 doi "https://doi.org/10.1097/00003246-199901000-00052" @default.
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