FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993670774> ?p ?o ?g. }

• W1993670774 endingPage "792" @default.
• W1993670774 startingPage "783" @default.
• W1993670774 abstract "Cartilage oligomeric matrix protein (COMP) is an extracellular matrix protein expressed in cartilage, ligament, and tendon. The importance of COMP in the matrix of these cells is underscored by the discovery that mutations in COMP cause the skeletal dysplasias, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (EDM1). Here, we present the first report on the analysis of the human COMP promoter region in cartilage, ligament, and tendon cells. A 1.7-kb region of the COMP promoter has been cloned and sequenced and no TATA or CAAT boxes were found. Primer extension identified multiple transcription start sites. All four transcription start sites were utilized in chondrocytes with only three of them utilized in tendon and ligament cells. Differential regulation was observed for different parts of this 1.7-kb region with the 370-bp proximal region conveying the strongest promoter activity. The highest activity was observed in tendon and ligament. Finally, we provide evidence that the DNA binding protein SP1 plays a role in the regulation of COMP expression. These results indicate that COMP expression within these cells is regulated in a unique manner that differs from the expression of other extracellular matrix genes." @default.
• W1993670774 created "2016-06-24" @default.
• W1993670774 creator A5030596121 @default.
• W1993670774 creator A5031862753 @default.
• W1993670774 creator A5047058365 @default.
• W1993670774 creator A5051913457 @default.
• W1993670774 creator A5060163897 @default.
• W1993670774 creator A5077076733 @default.
• W1993670774 date "2001-01-01" @default.
• W1993670774 modified "2023-09-25" @default.
• W1993670774 title "Analysis of the promoter region of human cartilage oligomeric matrix protein (COMP)" @default.
• W1993670774 cites W1500109073 @default.
• W1993670774 cites W1501863981 @default.
• W1993670774 cites W1555964835 @default.
• W1993670774 cites W1557792852 @default.
• W1993670774 cites W1964055102 @default.
• W1993670774 cites W1964442086 @default.
• W1993670774 cites W1967777610 @default.
• W1993670774 cites W1968471497 @default.
• W1993670774 cites W1969366516 @default.
• W1993670774 cites W1980142494 @default.
• W1993670774 cites W1990677902 @default.
• W1993670774 cites W1995388717 @default.
• W1993670774 cites W2005259839 @default.
• W1993670774 cites W2025986180 @default.
• W1993670774 cites W2042945854 @default.
• W1993670774 cites W2056574799 @default.
• W1993670774 cites W2069262765 @default.
• W1993670774 cites W2077281979 @default.
• W1993670774 cites W2080446840 @default.
• W1993670774 cites W2090567773 @default.
• W1993670774 cites W2135636594 @default.
• W1993670774 cites W2139938769 @default.
• W1993670774 cites W2141237296 @default.
• W1993670774 cites W2151708616 @default.
• W1993670774 doi "https://doi.org/10.1016/s0945-053x(00)00127-x" @default.
• W1993670774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11223338" @default.
• W1993670774 hasPublicationYear "2001" @default.
• W1993670774 type Work @default.
• W1993670774 sameAs 1993670774 @default.
• W1993670774 citedByCount "17" @default.
• W1993670774 countsByYear W19936707742012 @default.
• W1993670774 countsByYear W19936707742019 @default.
• W1993670774 crossrefType "journal-article" @default.
• W1993670774 hasAuthorship W1993670774A5030596121 @default.
• W1993670774 hasAuthorship W1993670774A5031862753 @default.
• W1993670774 hasAuthorship W1993670774A5047058365 @default.
• W1993670774 hasAuthorship W1993670774A5051913457 @default.
• W1993670774 hasAuthorship W1993670774A5060163897 @default.
• W1993670774 hasAuthorship W1993670774A5077076733 @default.
• W1993670774 hasConcept C101762097 @default.
• W1993670774 hasConcept C104317684 @default.
• W1993670774 hasConcept C105702510 @default.
• W1993670774 hasConcept C142724271 @default.
• W1993670774 hasConcept C150194340 @default.
• W1993670774 hasConcept C153911025 @default.
• W1993670774 hasConcept C189165786 @default.
• W1993670774 hasConcept C204787440 @default.
• W1993670774 hasConcept C2776164576 @default.
• W1993670774 hasConcept C2778232976 @default.
• W1993670774 hasConcept C2779753412 @default.
• W1993670774 hasConcept C2780105995 @default.
• W1993670774 hasConcept C2780550940 @default.
• W1993670774 hasConcept C54355233 @default.
• W1993670774 hasConcept C65888428 @default.
• W1993670774 hasConcept C71924100 @default.
• W1993670774 hasConcept C86339819 @default.
• W1993670774 hasConcept C86803240 @default.
• W1993670774 hasConcept C95444343 @default.
• W1993670774 hasConceptScore W1993670774C101762097 @default.
• W1993670774 hasConceptScore W1993670774C104317684 @default.
• W1993670774 hasConceptScore W1993670774C105702510 @default.
• W1993670774 hasConceptScore W1993670774C142724271 @default.
• W1993670774 hasConceptScore W1993670774C150194340 @default.
• W1993670774 hasConceptScore W1993670774C153911025 @default.
• W1993670774 hasConceptScore W1993670774C189165786 @default.
• W1993670774 hasConceptScore W1993670774C204787440 @default.
• W1993670774 hasConceptScore W1993670774C2776164576 @default.
• W1993670774 hasConceptScore W1993670774C2778232976 @default.
• W1993670774 hasConceptScore W1993670774C2779753412 @default.
• W1993670774 hasConceptScore W1993670774C2780105995 @default.
• W1993670774 hasConceptScore W1993670774C2780550940 @default.
• W1993670774 hasConceptScore W1993670774C54355233 @default.
• W1993670774 hasConceptScore W1993670774C65888428 @default.
• W1993670774 hasConceptScore W1993670774C71924100 @default.
• W1993670774 hasConceptScore W1993670774C86339819 @default.
• W1993670774 hasConceptScore W1993670774C86803240 @default.
• W1993670774 hasConceptScore W1993670774C95444343 @default.
• W1993670774 hasIssue "8" @default.
• W1993670774 hasLocation W19936707741 @default.
• W1993670774 hasLocation W19936707742 @default.
• W1993670774 hasOpenAccess W1993670774 @default.
• W1993670774 hasPrimaryLocation W19936707741 @default.
• W1993670774 hasRelatedWork W131141198 @default.
• W1993670774 hasRelatedWork W1979237794 @default.
• W1993670774 hasRelatedWork W2006536738 @default.
• W1993670774 hasRelatedWork W2009966535 @default.
• W1993670774 hasRelatedWork W2046006027 @default.

• next